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Ultrastructure of dorsal root ganglia

Dorsal root ganglia (DRG) contains thousands of sensory neurons that transmit information about our external and internal environment to the central nervous system. This includes signals related to proprioception, temperature, and nociception. Our understanding of DRG has increased tremendously over...

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Autores principales: Haberberger, Rainer Viktor, Kuramatilake, Jaliya, Barry, Christine M, Matusica, Dusan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115609/
https://www.ncbi.nlm.nih.gov/pubmed/37079097
http://dx.doi.org/10.1007/s00441-023-03770-w
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author Haberberger, Rainer Viktor
Kuramatilake, Jaliya
Barry, Christine M
Matusica, Dusan
author_facet Haberberger, Rainer Viktor
Kuramatilake, Jaliya
Barry, Christine M
Matusica, Dusan
author_sort Haberberger, Rainer Viktor
collection PubMed
description Dorsal root ganglia (DRG) contains thousands of sensory neurons that transmit information about our external and internal environment to the central nervous system. This includes signals related to proprioception, temperature, and nociception. Our understanding of DRG has increased tremendously over the last 50 years and has established the DRG as an active participant in peripheral processes. This includes interactions between neurons and non-neuronal cells such as satellite glia cells and macrophages that contribute to an increasingly complex cellular environment that modulates neuronal function. Early ultrastructural investigations of the DRG have described subtypes of sensory neurons based on differences in the arrangement of organelles such as the Golgi apparatus and the endoplasmic reticulum. The neuron-satellite cell complex and the composition of the axon hillock in DRG have also been investigated, but, apart from basic descriptions of Schwann cells, ultrastructural investigations of other cell types in DRG are limited. Furthermore, detailed descriptions of key components of DRG, such as blood vessels and the capsule that sits at the intersection of the meninges and the connective tissue covering the peripheral nervous system, are lacking to date. With rising interest in DRG as potential therapeutic targets for aberrant signalling associated with chronic pain conditions, gaining further insights into DRG ultrastructure will be fundamental to understanding cell–cell interactions that modulate DRG function. In this review, we aim to provide a synopsis of the current state of knowledge on the ultrastructure of the DRG and its components, as well as to identify areas of interest for future studies.
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spelling pubmed-101156092023-04-25 Ultrastructure of dorsal root ganglia Haberberger, Rainer Viktor Kuramatilake, Jaliya Barry, Christine M Matusica, Dusan Cell Tissue Res Review Dorsal root ganglia (DRG) contains thousands of sensory neurons that transmit information about our external and internal environment to the central nervous system. This includes signals related to proprioception, temperature, and nociception. Our understanding of DRG has increased tremendously over the last 50 years and has established the DRG as an active participant in peripheral processes. This includes interactions between neurons and non-neuronal cells such as satellite glia cells and macrophages that contribute to an increasingly complex cellular environment that modulates neuronal function. Early ultrastructural investigations of the DRG have described subtypes of sensory neurons based on differences in the arrangement of organelles such as the Golgi apparatus and the endoplasmic reticulum. The neuron-satellite cell complex and the composition of the axon hillock in DRG have also been investigated, but, apart from basic descriptions of Schwann cells, ultrastructural investigations of other cell types in DRG are limited. Furthermore, detailed descriptions of key components of DRG, such as blood vessels and the capsule that sits at the intersection of the meninges and the connective tissue covering the peripheral nervous system, are lacking to date. With rising interest in DRG as potential therapeutic targets for aberrant signalling associated with chronic pain conditions, gaining further insights into DRG ultrastructure will be fundamental to understanding cell–cell interactions that modulate DRG function. In this review, we aim to provide a synopsis of the current state of knowledge on the ultrastructure of the DRG and its components, as well as to identify areas of interest for future studies. Springer Berlin Heidelberg 2023-04-20 2023 /pmc/articles/PMC10115609/ /pubmed/37079097 http://dx.doi.org/10.1007/s00441-023-03770-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Haberberger, Rainer Viktor
Kuramatilake, Jaliya
Barry, Christine M
Matusica, Dusan
Ultrastructure of dorsal root ganglia
title Ultrastructure of dorsal root ganglia
title_full Ultrastructure of dorsal root ganglia
title_fullStr Ultrastructure of dorsal root ganglia
title_full_unstemmed Ultrastructure of dorsal root ganglia
title_short Ultrastructure of dorsal root ganglia
title_sort ultrastructure of dorsal root ganglia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115609/
https://www.ncbi.nlm.nih.gov/pubmed/37079097
http://dx.doi.org/10.1007/s00441-023-03770-w
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