Two Cases of Immune Checkpoint Inhibitor-Induced Myocarditis With Complete Atrioventricular Block

Immune checkpoint inhibitor-induced myocarditis (ICIM) has been reported to be complicated by a complete atrioventricular block. Even though steroids are used in the treatment thereof, there is no standard protocol for their use. We report two cases of ICIM with a complete atrioventricular block wit...

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Detalles Bibliográficos
Autores principales: Kondo, Hisaya, Kirigaya, Jin, Matsuzawa, Yasushi, Hibi, Kiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Cardiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115746/
https://www.ncbi.nlm.nih.gov/pubmed/37090337
http://dx.doi.org/10.7759/cureus.36446
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author Kondo, Hisaya
Kirigaya, Jin
Matsuzawa, Yasushi
Hibi, Kiyoshi
author_facet Kondo, Hisaya
Kirigaya, Jin
Matsuzawa, Yasushi
Hibi, Kiyoshi
author_sort Kondo, Hisaya
collection PubMed
description Immune checkpoint inhibitor-induced myocarditis (ICIM) has been reported to be complicated by a complete atrioventricular block. Even though steroids are used in the treatment thereof, there is no standard protocol for their use. We report two cases of ICIM with a complete atrioventricular block with different outcomes. In the first case, the complete atrioventricular block did not recover. In contrast, in the second case, the complete atrioventricular block did recover. We discuss the different courses and outcomes of the two cases in relation to steroid use.
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spelling pubmed-101157462023-04-21 Two Cases of Immune Checkpoint Inhibitor-Induced Myocarditis With Complete Atrioventricular Block Kondo, Hisaya Kirigaya, Jin Matsuzawa, Yasushi Hibi, Kiyoshi Cureus Cardiology Immune checkpoint inhibitor-induced myocarditis (ICIM) has been reported to be complicated by a complete atrioventricular block. Even though steroids are used in the treatment thereof, there is no standard protocol for their use. We report two cases of ICIM with a complete atrioventricular block with different outcomes. In the first case, the complete atrioventricular block did not recover. In contrast, in the second case, the complete atrioventricular block did recover. We discuss the different courses and outcomes of the two cases in relation to steroid use. Cureus 2023-03-21 /pmc/articles/PMC10115746/ /pubmed/37090337 http://dx.doi.org/10.7759/cureus.36446 Text en Copyright © 2023, Kondo et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Cardiology
Kondo, Hisaya
Kirigaya, Jin
Matsuzawa, Yasushi
Hibi, Kiyoshi
Two Cases of Immune Checkpoint Inhibitor-Induced Myocarditis With Complete Atrioventricular Block
title Two Cases of Immune Checkpoint Inhibitor-Induced Myocarditis With Complete Atrioventricular Block
title_full Two Cases of Immune Checkpoint Inhibitor-Induced Myocarditis With Complete Atrioventricular Block
title_fullStr Two Cases of Immune Checkpoint Inhibitor-Induced Myocarditis With Complete Atrioventricular Block
title_full_unstemmed Two Cases of Immune Checkpoint Inhibitor-Induced Myocarditis With Complete Atrioventricular Block
title_short Two Cases of Immune Checkpoint Inhibitor-Induced Myocarditis With Complete Atrioventricular Block
title_sort two cases of immune checkpoint inhibitor-induced myocarditis with complete atrioventricular block
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115746/
https://www.ncbi.nlm.nih.gov/pubmed/37090337
http://dx.doi.org/10.7759/cureus.36446
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