Allosteric role of the citrate synthase homology domain of ATP citrate lyase

ATP citrate lyase (ACLY) is the predominant nucleocytosolic source of acetyl-CoA and is aberrantly regulated in many diseases making it an attractive therapeutic target. Structural studies of ACLY reveal a central homotetrameric core citrate synthase homology (CSH) module flanked by acyl-CoA synthet...

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Detalles Bibliográficos
Autores principales: Wei, Xuepeng, Schultz, Kollin, Pepper, Hannah L., Megill, Emily, Vogt, Austin, Snyder, Nathaniel W., Marmorstein, Ronen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115795/
https://www.ncbi.nlm.nih.gov/pubmed/37076498
http://dx.doi.org/10.1038/s41467-023-37986-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115795/
https://www.ncbi.nlm.nih.gov/pubmed/37076498
http://dx.doi.org/10.1038/s41467-023-37986-9

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