Integrating genetics and transcriptomics to study major depressive disorder: a conceptual framework, bioinformatic approaches, and recent findings

Major depressive disorder (MDD) is a complex and heterogeneous psychiatric syndrome with genetic and environmental influences. In addition to neuroanatomical and circuit-level disturbances, dysregulation of the brain transcriptome is a key phenotypic signature of MDD. Postmortem brain gene expressio...

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Detalles Bibliográficos
Autores principales: Hicks, Emily M., Seah, Carina, Cote, Alanna, Marchese, Shelby, Brennand, Kristen J., Nestler, Eric J., Girgenti, Matthew J., Huckins, Laura M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115809/
https://www.ncbi.nlm.nih.gov/pubmed/37076454
http://dx.doi.org/10.1038/s41398-023-02412-7

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