Neuronopathic Gaucher disease models reveal defects in cell growth promoted by Hippo pathway activation

Gaucher Disease (GD), the most common lysosomal disorder, arises from mutations in the GBA1 gene and is characterized by a wide spectrum of phenotypes, ranging from mild hematological and visceral involvement to severe neurological disease. Neuronopathic patients display dramatic neuronal loss and i...

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Detalles Bibliográficos
Autores principales: Messelodi, Daria, Strocchi, Silvia, Bertuccio, Salvatore Nicola, Baden, Pascale, Indio, Valentina, Giorgi, Federico M., Taddia, Alberto, Serravalle, Salvatore, Valente, Sabrina, di Fonzo, Alessio, Frattini, Emanuele, Bernardoni, Roberto, Pession, Annalisa, Grifoni, Daniela, Deleidi, Michela, Astolfi, Annalisa, Pession, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115838/
https://www.ncbi.nlm.nih.gov/pubmed/37076591
http://dx.doi.org/10.1038/s42003-023-04813-2

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