Long-term expansion of human hematopoietic stem cells

Hematopoietic stem cells (HSCs) are critical for the treatment of a variety of hematological diseases. However, the low number of HSCs lead to the clinical application difficult. To gain more functional human HSCs ex vivo, Sakurai et al. established a recombinant-cytokine-free and albumin-free cultu...

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Detalles Bibliográficos
Autores principales: Liang, Guixian, Liu, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115916/
https://www.ncbi.nlm.nih.gov/pubmed/37074595
http://dx.doi.org/10.1186/s13619-023-00163-w
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author Liang, Guixian
Liu, Feng
author_facet Liang, Guixian
Liu, Feng
author_sort Liang, Guixian
collection PubMed
description Hematopoietic stem cells (HSCs) are critical for the treatment of a variety of hematological diseases. However, the low number of HSCs lead to the clinical application difficult. To gain more functional human HSCs ex vivo, Sakurai et al. established a recombinant-cytokine-free and albumin-free culture system, i.e. PCL-PVAc-PEG-based culture, in combination with 740Y-P, butyzamide and UM171, to improve the long-term expansion of human cord blood HSCs.
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spelling pubmed-101159162023-04-21 Long-term expansion of human hematopoietic stem cells Liang, Guixian Liu, Feng Cell Regen Research Highlight Hematopoietic stem cells (HSCs) are critical for the treatment of a variety of hematological diseases. However, the low number of HSCs lead to the clinical application difficult. To gain more functional human HSCs ex vivo, Sakurai et al. established a recombinant-cytokine-free and albumin-free culture system, i.e. PCL-PVAc-PEG-based culture, in combination with 740Y-P, butyzamide and UM171, to improve the long-term expansion of human cord blood HSCs. Springer Nature Singapore 2023-04-19 /pmc/articles/PMC10115916/ /pubmed/37074595 http://dx.doi.org/10.1186/s13619-023-00163-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Highlight
Liang, Guixian
Liu, Feng
Long-term expansion of human hematopoietic stem cells
title Long-term expansion of human hematopoietic stem cells
title_full Long-term expansion of human hematopoietic stem cells
title_fullStr Long-term expansion of human hematopoietic stem cells
title_full_unstemmed Long-term expansion of human hematopoietic stem cells
title_short Long-term expansion of human hematopoietic stem cells
title_sort long-term expansion of human hematopoietic stem cells
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115916/
https://www.ncbi.nlm.nih.gov/pubmed/37074595
http://dx.doi.org/10.1186/s13619-023-00163-w
work_keys_str_mv AT liangguixian longtermexpansionofhumanhematopoieticstemcells
AT liufeng longtermexpansionofhumanhematopoieticstemcells

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