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Endemic melioidosis in central Taiwan—A longitudinal case cohort study
BACKGROUND: Melioidosis is a systemic and suppurative disease endemic in the Southeast Asia. In Taiwan, most cases are reported in the southern region and no relevant profiles have been reported in central region. In this study, we performed the epidemiologic and clinical analyses from the melioidos...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115954/ https://www.ncbi.nlm.nih.gov/pubmed/37089599 http://dx.doi.org/10.3389/fmed.2023.1131788 |
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author | Ling, Ting Ting Lee, Su-Yin Tsao, Shih-Ming Liang, Keng-Wei Wang, Wei-Yao |
author_facet | Ling, Ting Ting Lee, Su-Yin Tsao, Shih-Ming Liang, Keng-Wei Wang, Wei-Yao |
author_sort | Ling, Ting Ting |
collection | PubMed |
description | BACKGROUND: Melioidosis is a systemic and suppurative disease endemic in the Southeast Asia. In Taiwan, most cases are reported in the southern region and no relevant profiles have been reported in central region. In this study, we performed the epidemiologic and clinical analyses from the melioidosis cases in central Taiwan. METHODS: The demographic, clinical, laboratory, radiologic, and outcome profiles were collected retrospectively and analyzed from patients whom Burkhoderia pseudomallei was isolated from clinical specimens during the 12-year study period (2011–2022). RESULTS: Totally 11 melioidosis cases (10 males and 1 female) were diagnosed, among them only 2 (18.2%) cases lived in suburban areas. Seven (63.6%) cases were diagnosed during 2019–2020, and diabetes mellitus was the most relevant comorbidity (5, 45.4%). All cases presented with fever at arrival, but only 4 (36.4%) and 2 (18.2%) cases presented with dyspnea and shock, respectively. Pneumonitis and extrapulmonary involvement were found in 5 cases (45.4%) each. Appropriate empiric and targeted antibiotic treatments were found in 4 (36.4%) and 10 (91.0%) case, respectively. Two cases (18.2%) succumbed to infection despite appropriate treatment including targeted antibiotics. CONCLUSION: Melioidosis has become endemic in central Taiwan. Septic patients who present with suppurative or undetermined foci and have unsatisfied responses to standard treatment should arouse clinicians to take melioidosis into consideration. |
format | Online Article Text |
id | pubmed-10115954 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101159542023-04-21 Endemic melioidosis in central Taiwan—A longitudinal case cohort study Ling, Ting Ting Lee, Su-Yin Tsao, Shih-Ming Liang, Keng-Wei Wang, Wei-Yao Front Med (Lausanne) Medicine BACKGROUND: Melioidosis is a systemic and suppurative disease endemic in the Southeast Asia. In Taiwan, most cases are reported in the southern region and no relevant profiles have been reported in central region. In this study, we performed the epidemiologic and clinical analyses from the melioidosis cases in central Taiwan. METHODS: The demographic, clinical, laboratory, radiologic, and outcome profiles were collected retrospectively and analyzed from patients whom Burkhoderia pseudomallei was isolated from clinical specimens during the 12-year study period (2011–2022). RESULTS: Totally 11 melioidosis cases (10 males and 1 female) were diagnosed, among them only 2 (18.2%) cases lived in suburban areas. Seven (63.6%) cases were diagnosed during 2019–2020, and diabetes mellitus was the most relevant comorbidity (5, 45.4%). All cases presented with fever at arrival, but only 4 (36.4%) and 2 (18.2%) cases presented with dyspnea and shock, respectively. Pneumonitis and extrapulmonary involvement were found in 5 cases (45.4%) each. Appropriate empiric and targeted antibiotic treatments were found in 4 (36.4%) and 10 (91.0%) case, respectively. Two cases (18.2%) succumbed to infection despite appropriate treatment including targeted antibiotics. CONCLUSION: Melioidosis has become endemic in central Taiwan. Septic patients who present with suppurative or undetermined foci and have unsatisfied responses to standard treatment should arouse clinicians to take melioidosis into consideration. Frontiers Media S.A. 2023-04-06 /pmc/articles/PMC10115954/ /pubmed/37089599 http://dx.doi.org/10.3389/fmed.2023.1131788 Text en Copyright © 2023 Ling, Lee, Tsao, Liang and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Ling, Ting Ting Lee, Su-Yin Tsao, Shih-Ming Liang, Keng-Wei Wang, Wei-Yao Endemic melioidosis in central Taiwan—A longitudinal case cohort study |
title | Endemic melioidosis in central Taiwan—A longitudinal case cohort study |
title_full | Endemic melioidosis in central Taiwan—A longitudinal case cohort study |
title_fullStr | Endemic melioidosis in central Taiwan—A longitudinal case cohort study |
title_full_unstemmed | Endemic melioidosis in central Taiwan—A longitudinal case cohort study |
title_short | Endemic melioidosis in central Taiwan—A longitudinal case cohort study |
title_sort | endemic melioidosis in central taiwan—a longitudinal case cohort study |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115954/ https://www.ncbi.nlm.nih.gov/pubmed/37089599 http://dx.doi.org/10.3389/fmed.2023.1131788 |
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