Role of CD147 in the development and diagnosis of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the most common primary liver cancer, and the third leading cause of cancer-related deaths worldwide. HCC is characterized by insidious onset, and most patients are diagnosed at an advanced stage with a poor prognosis. Identification of biomarkers for HCC onset and...

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Autores principales: Huang, Defa, Rao, Dingyu, Jin, Qing, Lai, Mi, Zhang, Jiali, Lai, Zhonghong, Shen, Haibin, Zhong, Tianyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115957/
https://www.ncbi.nlm.nih.gov/pubmed/37090718
http://dx.doi.org/10.3389/fimmu.2023.1149931
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author Huang, Defa
Rao, Dingyu
Jin, Qing
Lai, Mi
Zhang, Jiali
Lai, Zhonghong
Shen, Haibin
Zhong, Tianyu
author_facet Huang, Defa
Rao, Dingyu
Jin, Qing
Lai, Mi
Zhang, Jiali
Lai, Zhonghong
Shen, Haibin
Zhong, Tianyu
author_sort Huang, Defa
collection PubMed
description Hepatocellular carcinoma (HCC) is the most common primary liver cancer, and the third leading cause of cancer-related deaths worldwide. HCC is characterized by insidious onset, and most patients are diagnosed at an advanced stage with a poor prognosis. Identification of biomarkers for HCC onset and progression is imperative to development of effective diagnostic and therapeutic strategies. CD147 is a glycoprotein that is involved in tumor cell invasion, metastasis and angiogenesis through multiple mechanisms. In this review, we describe the molecular structure of CD147 and its role in regulating HCC invasion, metastasis and angiogenesis. We highlight its potential as a diagnostic and therapeutic target for HCC.
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spelling pubmed-101159572023-04-21 Role of CD147 in the development and diagnosis of hepatocellular carcinoma Huang, Defa Rao, Dingyu Jin, Qing Lai, Mi Zhang, Jiali Lai, Zhonghong Shen, Haibin Zhong, Tianyu Front Immunol Immunology Hepatocellular carcinoma (HCC) is the most common primary liver cancer, and the third leading cause of cancer-related deaths worldwide. HCC is characterized by insidious onset, and most patients are diagnosed at an advanced stage with a poor prognosis. Identification of biomarkers for HCC onset and progression is imperative to development of effective diagnostic and therapeutic strategies. CD147 is a glycoprotein that is involved in tumor cell invasion, metastasis and angiogenesis through multiple mechanisms. In this review, we describe the molecular structure of CD147 and its role in regulating HCC invasion, metastasis and angiogenesis. We highlight its potential as a diagnostic and therapeutic target for HCC. Frontiers Media S.A. 2023-04-06 /pmc/articles/PMC10115957/ /pubmed/37090718 http://dx.doi.org/10.3389/fimmu.2023.1149931 Text en Copyright © 2023 Huang, Rao, Jin, Lai, Zhang, Lai, Shen and Zhong https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Huang, Defa
Rao, Dingyu
Jin, Qing
Lai, Mi
Zhang, Jiali
Lai, Zhonghong
Shen, Haibin
Zhong, Tianyu
Role of CD147 in the development and diagnosis of hepatocellular carcinoma
title Role of CD147 in the development and diagnosis of hepatocellular carcinoma
title_full Role of CD147 in the development and diagnosis of hepatocellular carcinoma
title_fullStr Role of CD147 in the development and diagnosis of hepatocellular carcinoma
title_full_unstemmed Role of CD147 in the development and diagnosis of hepatocellular carcinoma
title_short Role of CD147 in the development and diagnosis of hepatocellular carcinoma
title_sort role of cd147 in the development and diagnosis of hepatocellular carcinoma
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115957/
https://www.ncbi.nlm.nih.gov/pubmed/37090718
http://dx.doi.org/10.3389/fimmu.2023.1149931
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