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Prognostic significance of TMEM131L in glioma and establishment of oxidative stress prognostic model

Gliomas are the most aggressive of all brain tumors. In this study, it was found that there is a significant expression of transmembrane-like 131 (TMEM131L) in glioma tissues. The relevance of TMEM131L in the diagnosis and clinical prognosis of GBM and LGG was verified by additional clinical correla...

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Autores principales: Shan, Li, Zhu, Xiaoli, Qiu, Hui-Zhu, Zuo, Er-Dong, Cheng, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115999/
https://www.ncbi.nlm.nih.gov/pubmed/37090987
http://dx.doi.org/10.3389/fneur.2023.1162394
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author Shan, Li
Zhu, Xiaoli
Qiu, Hui-Zhu
Zuo, Er-Dong
Cheng, Xu
author_facet Shan, Li
Zhu, Xiaoli
Qiu, Hui-Zhu
Zuo, Er-Dong
Cheng, Xu
author_sort Shan, Li
collection PubMed
description Gliomas are the most aggressive of all brain tumors. In this study, it was found that there is a significant expression of transmembrane-like 131 (TMEM131L) in glioma tissues. The relevance of TMEM131L in the diagnosis and clinical prognosis of GBM and LGG was verified by additional clinical correlation and survival analysis. The area under the curve (AUC) of the receiver operating characteristic (ROC) curve reflected the diagnostic effect of TMEM131L on the clinicopathologic features of glioma. As a unique molecular marker for the poor prognosis of overall survival (OS), PFI, and DSS in patients with GCB and LGG, TMEM131L might be employed, according to time-dependent ROC curves and Kaplan–Meier survival analysis at 1, 3, and 5 years. The potential methylation sites of TMEM131L were selected by correlation analysis between TMEM131L and DNA methylation sites. Meanwhile, TMEM131L was significantly correlated with matrix, immunity, and estimated scores of GBM and LGG. The CIBERSORT analysis revealed a significant correlation between immune checkpoint and infiltration of 22 different kinds of immune cells. Coexpression genes of TMEM131L associated with oxidative stress phenotype were screened by the LASSO logistic regression analysis. Nomogram and calibration curves further confirmed that the prognostic model composed of SYT1, CREB3L3, ITPR1, RASGRF2, PDX1, and RASGRF1 has good stability and potential application value for poor prognosis in patients with glioma.
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spelling pubmed-101159992023-04-21 Prognostic significance of TMEM131L in glioma and establishment of oxidative stress prognostic model Shan, Li Zhu, Xiaoli Qiu, Hui-Zhu Zuo, Er-Dong Cheng, Xu Front Neurol Neurology Gliomas are the most aggressive of all brain tumors. In this study, it was found that there is a significant expression of transmembrane-like 131 (TMEM131L) in glioma tissues. The relevance of TMEM131L in the diagnosis and clinical prognosis of GBM and LGG was verified by additional clinical correlation and survival analysis. The area under the curve (AUC) of the receiver operating characteristic (ROC) curve reflected the diagnostic effect of TMEM131L on the clinicopathologic features of glioma. As a unique molecular marker for the poor prognosis of overall survival (OS), PFI, and DSS in patients with GCB and LGG, TMEM131L might be employed, according to time-dependent ROC curves and Kaplan–Meier survival analysis at 1, 3, and 5 years. The potential methylation sites of TMEM131L were selected by correlation analysis between TMEM131L and DNA methylation sites. Meanwhile, TMEM131L was significantly correlated with matrix, immunity, and estimated scores of GBM and LGG. The CIBERSORT analysis revealed a significant correlation between immune checkpoint and infiltration of 22 different kinds of immune cells. Coexpression genes of TMEM131L associated with oxidative stress phenotype were screened by the LASSO logistic regression analysis. Nomogram and calibration curves further confirmed that the prognostic model composed of SYT1, CREB3L3, ITPR1, RASGRF2, PDX1, and RASGRF1 has good stability and potential application value for poor prognosis in patients with glioma. Frontiers Media S.A. 2023-04-06 /pmc/articles/PMC10115999/ /pubmed/37090987 http://dx.doi.org/10.3389/fneur.2023.1162394 Text en Copyright © 2023 Shan, Zhu, Qiu, Zuo and Cheng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Shan, Li
Zhu, Xiaoli
Qiu, Hui-Zhu
Zuo, Er-Dong
Cheng, Xu
Prognostic significance of TMEM131L in glioma and establishment of oxidative stress prognostic model
title Prognostic significance of TMEM131L in glioma and establishment of oxidative stress prognostic model
title_full Prognostic significance of TMEM131L in glioma and establishment of oxidative stress prognostic model
title_fullStr Prognostic significance of TMEM131L in glioma and establishment of oxidative stress prognostic model
title_full_unstemmed Prognostic significance of TMEM131L in glioma and establishment of oxidative stress prognostic model
title_short Prognostic significance of TMEM131L in glioma and establishment of oxidative stress prognostic model
title_sort prognostic significance of tmem131l in glioma and establishment of oxidative stress prognostic model
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10115999/
https://www.ncbi.nlm.nih.gov/pubmed/37090987
http://dx.doi.org/10.3389/fneur.2023.1162394
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