A Review of Hedgehog Signaling in Radioresistant Esophageal Cancer: Potential Treatment Target

Esophageal cancer is one of the most lethal malignancies worldwide. For locally advanced diseases, radiotherapy is the main treatment. The survival rates, however, are still appalling, which is partially due to radioresistance. In 6% of cases of esophageal cancer, the Hedgehog pathway is reactivated...

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Detalles Bibliográficos
Autores principales: Ma, Li, Wang, Yu, Chen, Peng, Wu, Shixiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Novel Biomarkers, Molecular Diagnostics and Targeted Therapies of Cancer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10116006/
https://www.ncbi.nlm.nih.gov/pubmed/37066520
http://dx.doi.org/10.1177/15330338231169873
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author Ma, Li
Wang, Yu
Chen, Peng
Wu, Shixiu
author_facet Ma, Li
Wang, Yu
Chen, Peng
Wu, Shixiu
author_sort Ma, Li
collection PubMed
description Esophageal cancer is one of the most lethal malignancies worldwide. For locally advanced diseases, radiotherapy is the main treatment. The survival rates, however, are still appalling, which is partially due to radioresistance. In 6% of cases of esophageal cancer, the Hedgehog pathway is reactivated, and this pathway is crucial for the growth, progression, treatment resistance, and metastasis of esophageal cancer. Here, we conducted a comprehensive review of the current research on Hedgehog pathway in esophageal cancer.
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spelling pubmed-101160062023-04-21 A Review of Hedgehog Signaling in Radioresistant Esophageal Cancer: Potential Treatment Target Ma, Li Wang, Yu Chen, Peng Wu, Shixiu Technol Cancer Res Treat Novel Biomarkers, Molecular Diagnostics and Targeted Therapies of Cancer Esophageal cancer is one of the most lethal malignancies worldwide. For locally advanced diseases, radiotherapy is the main treatment. The survival rates, however, are still appalling, which is partially due to radioresistance. In 6% of cases of esophageal cancer, the Hedgehog pathway is reactivated, and this pathway is crucial for the growth, progression, treatment resistance, and metastasis of esophageal cancer. Here, we conducted a comprehensive review of the current research on Hedgehog pathway in esophageal cancer. SAGE Publications 2023-04-17 /pmc/articles/PMC10116006/ /pubmed/37066520 http://dx.doi.org/10.1177/15330338231169873 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Novel Biomarkers, Molecular Diagnostics and Targeted Therapies of Cancer
Ma, Li
Wang, Yu
Chen, Peng
Wu, Shixiu
A Review of Hedgehog Signaling in Radioresistant Esophageal Cancer: Potential Treatment Target
title A Review of Hedgehog Signaling in Radioresistant Esophageal Cancer: Potential Treatment Target
title_full A Review of Hedgehog Signaling in Radioresistant Esophageal Cancer: Potential Treatment Target
title_fullStr A Review of Hedgehog Signaling in Radioresistant Esophageal Cancer: Potential Treatment Target
title_full_unstemmed A Review of Hedgehog Signaling in Radioresistant Esophageal Cancer: Potential Treatment Target
title_short A Review of Hedgehog Signaling in Radioresistant Esophageal Cancer: Potential Treatment Target
title_sort review of hedgehog signaling in radioresistant esophageal cancer: potential treatment target
topic Novel Biomarkers, Molecular Diagnostics and Targeted Therapies of Cancer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10116006/
https://www.ncbi.nlm.nih.gov/pubmed/37066520
http://dx.doi.org/10.1177/15330338231169873
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