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Effect of radiotherapy interruption on nasopharyngeal cancer

Nasopharyngeal carcinoma (NPC) is a malignant tumor originating from the epithelial cells of the nasopharynx with a unique geographic distribution, and is particularly prevalent in East and Southeast Asia. Due to its anatomical location, the surgery is difficult to access and the high sensitivity of...

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Detalles Bibliográficos
Autores principales: Zhao, Fangrui, Yang, Dashuai, Li, Xiangpan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10116059/
https://www.ncbi.nlm.nih.gov/pubmed/37091186
http://dx.doi.org/10.3389/fonc.2023.1114652
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author Zhao, Fangrui
Yang, Dashuai
Li, Xiangpan
author_facet Zhao, Fangrui
Yang, Dashuai
Li, Xiangpan
author_sort Zhao, Fangrui
collection PubMed
description Nasopharyngeal carcinoma (NPC) is a malignant tumor originating from the epithelial cells of the nasopharynx with a unique geographic distribution, and is particularly prevalent in East and Southeast Asia. Due to its anatomical location, the surgery is difficult to access and the high sensitivity of nasopharyngeal cancer to radiotherapy (RT) makes it the main treatment modality. Radical radiotherapy is the first-line treatment for early-stage nasopharyngeal carcinoma and the cornerstone of multidisciplinary treatment for patients with locally advanced nasopharyngeal carcinoma. Nevertheless, radiotherapy interruption is inevitable as a consequence of unavoidable factors such as public holidays, machine malfunction, patient compliance, and adverse response to treatment, which in turn leads to a reduction in bioactivity and causes sublethal loss of tumor cells to repair. Unirradiated tumor cells are more likely to repopulate at or near their original fastest growth rate during this interval. If no measures are taken after the radiotherapy interruption, such as increasing the dose of radiotherapy and systemic therapy, the tumor is most likely to go uncontrolled and then progress. This review describes the effects of radiotherapy interruption on nasopharyngeal carcinoma, the mechanism of the effect, and explores the measures that can be taken in response to such interruption.
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spelling pubmed-101160592023-04-21 Effect of radiotherapy interruption on nasopharyngeal cancer Zhao, Fangrui Yang, Dashuai Li, Xiangpan Front Oncol Oncology Nasopharyngeal carcinoma (NPC) is a malignant tumor originating from the epithelial cells of the nasopharynx with a unique geographic distribution, and is particularly prevalent in East and Southeast Asia. Due to its anatomical location, the surgery is difficult to access and the high sensitivity of nasopharyngeal cancer to radiotherapy (RT) makes it the main treatment modality. Radical radiotherapy is the first-line treatment for early-stage nasopharyngeal carcinoma and the cornerstone of multidisciplinary treatment for patients with locally advanced nasopharyngeal carcinoma. Nevertheless, radiotherapy interruption is inevitable as a consequence of unavoidable factors such as public holidays, machine malfunction, patient compliance, and adverse response to treatment, which in turn leads to a reduction in bioactivity and causes sublethal loss of tumor cells to repair. Unirradiated tumor cells are more likely to repopulate at or near their original fastest growth rate during this interval. If no measures are taken after the radiotherapy interruption, such as increasing the dose of radiotherapy and systemic therapy, the tumor is most likely to go uncontrolled and then progress. This review describes the effects of radiotherapy interruption on nasopharyngeal carcinoma, the mechanism of the effect, and explores the measures that can be taken in response to such interruption. Frontiers Media S.A. 2023-04-06 /pmc/articles/PMC10116059/ /pubmed/37091186 http://dx.doi.org/10.3389/fonc.2023.1114652 Text en Copyright © 2023 Zhao, Yang and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zhao, Fangrui
Yang, Dashuai
Li, Xiangpan
Effect of radiotherapy interruption on nasopharyngeal cancer
title Effect of radiotherapy interruption on nasopharyngeal cancer
title_full Effect of radiotherapy interruption on nasopharyngeal cancer
title_fullStr Effect of radiotherapy interruption on nasopharyngeal cancer
title_full_unstemmed Effect of radiotherapy interruption on nasopharyngeal cancer
title_short Effect of radiotherapy interruption on nasopharyngeal cancer
title_sort effect of radiotherapy interruption on nasopharyngeal cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10116059/
https://www.ncbi.nlm.nih.gov/pubmed/37091186
http://dx.doi.org/10.3389/fonc.2023.1114652
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