Cargando…
The Prevention of Inflammation and the Maintenance of Iron and Hepcidin Homeostasis in the Gut, Liver, and Brain Pathologies
The human gut microbiome consists of a variety of microorganisms that inhabit the intestinal tract. This flora has recently been shown to play an important role in human disease. The crosstalk between the gut and brain axis has been investigated through hepcidin, derived from both hepatocytes and de...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10116142/ https://www.ncbi.nlm.nih.gov/pubmed/36846996 http://dx.doi.org/10.3233/JAD-220224 |
_version_ | 1785028360586395648 |
---|---|
author | Kania, Barbara Sotelo, Alexis Ty, Darren Wisco, Jonathan J. |
author_facet | Kania, Barbara Sotelo, Alexis Ty, Darren Wisco, Jonathan J. |
author_sort | Kania, Barbara |
collection | PubMed |
description | The human gut microbiome consists of a variety of microorganisms that inhabit the intestinal tract. This flora has recently been shown to play an important role in human disease. The crosstalk between the gut and brain axis has been investigated through hepcidin, derived from both hepatocytes and dendritic cells. Hepcidin could potentially play an anti-inflammatory role in the process of gut dysbiosis through a means of either a localized approach of nutritional immunity, or a systemic approach. Like hepcidin, mBDNF and IL-6 are part of the gut-brain axis: gut microbiota affects their levels of expression, and this relationship is thought to play a role in cognitive function and decline, which could ultimately lead to a number of neurodegenerative diseases such as Alzheimer’s disease. This review will focus on the interplay between gut dysbiosis and the crosstalk between the gut, liver, and brain and how this is mediated by hepcidin through different mechanisms including the vagus nerve and several different biomolecules. This overview will also focus on the gut microbiota-induced dysbiotic state on a systemic level, and how gut dysbiosis can contribute to beginnings and the progression of Alzheimer’s disease and neuroinflammation. |
format | Online Article Text |
id | pubmed-10116142 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-101161422023-04-21 The Prevention of Inflammation and the Maintenance of Iron and Hepcidin Homeostasis in the Gut, Liver, and Brain Pathologies Kania, Barbara Sotelo, Alexis Ty, Darren Wisco, Jonathan J. J Alzheimers Dis Review The human gut microbiome consists of a variety of microorganisms that inhabit the intestinal tract. This flora has recently been shown to play an important role in human disease. The crosstalk between the gut and brain axis has been investigated through hepcidin, derived from both hepatocytes and dendritic cells. Hepcidin could potentially play an anti-inflammatory role in the process of gut dysbiosis through a means of either a localized approach of nutritional immunity, or a systemic approach. Like hepcidin, mBDNF and IL-6 are part of the gut-brain axis: gut microbiota affects their levels of expression, and this relationship is thought to play a role in cognitive function and decline, which could ultimately lead to a number of neurodegenerative diseases such as Alzheimer’s disease. This review will focus on the interplay between gut dysbiosis and the crosstalk between the gut, liver, and brain and how this is mediated by hepcidin through different mechanisms including the vagus nerve and several different biomolecules. This overview will also focus on the gut microbiota-induced dysbiotic state on a systemic level, and how gut dysbiosis can contribute to beginnings and the progression of Alzheimer’s disease and neuroinflammation. IOS Press 2023-04-04 /pmc/articles/PMC10116142/ /pubmed/36846996 http://dx.doi.org/10.3233/JAD-220224 Text en © 2023 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Kania, Barbara Sotelo, Alexis Ty, Darren Wisco, Jonathan J. The Prevention of Inflammation and the Maintenance of Iron and Hepcidin Homeostasis in the Gut, Liver, and Brain Pathologies |
title | The Prevention of Inflammation and the Maintenance of Iron and Hepcidin Homeostasis in the Gut, Liver, and Brain Pathologies |
title_full | The Prevention of Inflammation and the Maintenance of Iron and Hepcidin Homeostasis in the Gut, Liver, and Brain Pathologies |
title_fullStr | The Prevention of Inflammation and the Maintenance of Iron and Hepcidin Homeostasis in the Gut, Liver, and Brain Pathologies |
title_full_unstemmed | The Prevention of Inflammation and the Maintenance of Iron and Hepcidin Homeostasis in the Gut, Liver, and Brain Pathologies |
title_short | The Prevention of Inflammation and the Maintenance of Iron and Hepcidin Homeostasis in the Gut, Liver, and Brain Pathologies |
title_sort | prevention of inflammation and the maintenance of iron and hepcidin homeostasis in the gut, liver, and brain pathologies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10116142/ https://www.ncbi.nlm.nih.gov/pubmed/36846996 http://dx.doi.org/10.3233/JAD-220224 |
work_keys_str_mv | AT kaniabarbara thepreventionofinflammationandthemaintenanceofironandhepcidinhomeostasisinthegutliverandbrainpathologies AT soteloalexis thepreventionofinflammationandthemaintenanceofironandhepcidinhomeostasisinthegutliverandbrainpathologies AT tydarren thepreventionofinflammationandthemaintenanceofironandhepcidinhomeostasisinthegutliverandbrainpathologies AT wiscojonathanj thepreventionofinflammationandthemaintenanceofironandhepcidinhomeostasisinthegutliverandbrainpathologies AT kaniabarbara preventionofinflammationandthemaintenanceofironandhepcidinhomeostasisinthegutliverandbrainpathologies AT soteloalexis preventionofinflammationandthemaintenanceofironandhepcidinhomeostasisinthegutliverandbrainpathologies AT tydarren preventionofinflammationandthemaintenanceofironandhepcidinhomeostasisinthegutliverandbrainpathologies AT wiscojonathanj preventionofinflammationandthemaintenanceofironandhepcidinhomeostasisinthegutliverandbrainpathologies |