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The Potential Role of Gustatory Function as an Early Diagnostic Marker for the Risk of Alzheimer’s Disease in Subjective Cognitive Decline

BACKGROUND: Patients with subjective cognitive decline (SCD) report memory deterioration and are at an increased risk of converting to Alzheimer’s disease (AD) although psychophysical testing does not reveal any cognitive deficit. OBJECTIVE: Here, gustatory function is investigated as a potential pr...

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Autores principales: Schmicker, Marlen, Frühling, Insa, Menze, Inga, Glanz, Wenzel, Müller, Patrick, Noesselt, Toemme, Müller, Notger G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10116167/
https://www.ncbi.nlm.nih.gov/pubmed/37090958
http://dx.doi.org/10.3233/ADR220092
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author Schmicker, Marlen
Frühling, Insa
Menze, Inga
Glanz, Wenzel
Müller, Patrick
Noesselt, Toemme
Müller, Notger G.
author_facet Schmicker, Marlen
Frühling, Insa
Menze, Inga
Glanz, Wenzel
Müller, Patrick
Noesselt, Toemme
Müller, Notger G.
author_sort Schmicker, Marlen
collection PubMed
description BACKGROUND: Patients with subjective cognitive decline (SCD) report memory deterioration and are at an increased risk of converting to Alzheimer’s disease (AD) although psychophysical testing does not reveal any cognitive deficit. OBJECTIVE: Here, gustatory function is investigated as a potential predictor for an increased risk of progressive cognitive decline indicating higher AD risk in SCD. METHODS: Measures of smell and taste perception as well as neuropsychological data were assessed in patients with subjective cognitive decline (SCD): Subgroups with an increased likelihood of the progression to preclinical AD (SCD+) and those with a lower likelihood (SCD–) were compared to healthy controls (HC), patients with mild cognitive impairment and AD patients. The Sniffin’ Sticks test contained 12 items with different qualities and taste was measured with 32 taste stripes (sweet, salty, bitter, sour) of different concentration. RESULTS: Only taste was able to distinguish between HC/SCD– and SCD+ patients. CONCLUSION: This study provides a first hint of taste as a more sensitive marker than smell for detecting preclinical AD in SCD. Longitudinal observation of cognition and pathology are necessary to further evaluate taste perception as a predictor of pathological objective decline in cognition.
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spelling pubmed-101161672023-04-21 The Potential Role of Gustatory Function as an Early Diagnostic Marker for the Risk of Alzheimer’s Disease in Subjective Cognitive Decline Schmicker, Marlen Frühling, Insa Menze, Inga Glanz, Wenzel Müller, Patrick Noesselt, Toemme Müller, Notger G. J Alzheimers Dis Rep Research Report BACKGROUND: Patients with subjective cognitive decline (SCD) report memory deterioration and are at an increased risk of converting to Alzheimer’s disease (AD) although psychophysical testing does not reveal any cognitive deficit. OBJECTIVE: Here, gustatory function is investigated as a potential predictor for an increased risk of progressive cognitive decline indicating higher AD risk in SCD. METHODS: Measures of smell and taste perception as well as neuropsychological data were assessed in patients with subjective cognitive decline (SCD): Subgroups with an increased likelihood of the progression to preclinical AD (SCD+) and those with a lower likelihood (SCD–) were compared to healthy controls (HC), patients with mild cognitive impairment and AD patients. The Sniffin’ Sticks test contained 12 items with different qualities and taste was measured with 32 taste stripes (sweet, salty, bitter, sour) of different concentration. RESULTS: Only taste was able to distinguish between HC/SCD– and SCD+ patients. CONCLUSION: This study provides a first hint of taste as a more sensitive marker than smell for detecting preclinical AD in SCD. Longitudinal observation of cognition and pathology are necessary to further evaluate taste perception as a predictor of pathological objective decline in cognition. IOS Press 2023-04-03 /pmc/articles/PMC10116167/ /pubmed/37090958 http://dx.doi.org/10.3233/ADR220092 Text en © 2023 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Report
Schmicker, Marlen
Frühling, Insa
Menze, Inga
Glanz, Wenzel
Müller, Patrick
Noesselt, Toemme
Müller, Notger G.
The Potential Role of Gustatory Function as an Early Diagnostic Marker for the Risk of Alzheimer’s Disease in Subjective Cognitive Decline
title The Potential Role of Gustatory Function as an Early Diagnostic Marker for the Risk of Alzheimer’s Disease in Subjective Cognitive Decline
title_full The Potential Role of Gustatory Function as an Early Diagnostic Marker for the Risk of Alzheimer’s Disease in Subjective Cognitive Decline
title_fullStr The Potential Role of Gustatory Function as an Early Diagnostic Marker for the Risk of Alzheimer’s Disease in Subjective Cognitive Decline
title_full_unstemmed The Potential Role of Gustatory Function as an Early Diagnostic Marker for the Risk of Alzheimer’s Disease in Subjective Cognitive Decline
title_short The Potential Role of Gustatory Function as an Early Diagnostic Marker for the Risk of Alzheimer’s Disease in Subjective Cognitive Decline
title_sort potential role of gustatory function as an early diagnostic marker for the risk of alzheimer’s disease in subjective cognitive decline
topic Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10116167/
https://www.ncbi.nlm.nih.gov/pubmed/37090958
http://dx.doi.org/10.3233/ADR220092
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