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Total Chemical Synthesis of Palmitoyl-Conjugated Insulin

[Image: see text] Commercially available insulins are manufactured by recombinant methods for the treatment of diabetes. Long-acting insulin drugs (e.g., detemir and degludec) are obtained by fatty acid conjugation at LysB29 ε-amine of insulin via acid–amide coupling. There are three amine groups in...

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Detalles Bibliográficos
Autores principales:	Liu, Mengjie, Li, Qingyang, Delaine, Carlie, Wu, Hongkang, Arsenakis, Yanni, White, Barbara F., Forbes, Briony E., Chandrashekar, Chaitra, Hossain, Mohammed Akhter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10116525/ https://www.ncbi.nlm.nih.gov/pubmed/37091377 http://dx.doi.org/10.1021/acsomega.2c07918

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