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Evaluating the role of anxiety on the association between irritable bowel syndrome and brain volumes: a mediation analysis in the UK Biobank cohort

There is a strong link between irritable bowel syndrome and brain volumes, yet, to date, research examining the mediators of this association has been little. Based on the phenotypic data of 15 248 participants from the UK Biobank, a two-stage mediation analysis was performed to assess the associati...

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Autores principales: Meng, Peilin, Cheng, Bolun, Pan, Chuyu, Liu, Li, Cheng, Shiqiang, Yang, Xuena, Chen, Yujing, Li, Chun’e, Zhang, Huijie, Zhang, Zhen, Zhang, Jingxi, He, Dan, Shi, Sirong, Chu, Xiaoge, Cai, Qingqing, Zhang, Na, Qin, Xiaoyue, Zhao, Yijing, Wei, Wenming, Jia, Yumeng, Wen, Yan, Zhang, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10116581/
https://www.ncbi.nlm.nih.gov/pubmed/37091589
http://dx.doi.org/10.1093/braincomms/fcad116
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author Meng, Peilin
Cheng, Bolun
Pan, Chuyu
Liu, Li
Cheng, Shiqiang
Yang, Xuena
Chen, Yujing
Li, Chun’e
Zhang, Huijie
Zhang, Zhen
Zhang, Jingxi
He, Dan
Shi, Sirong
Chu, Xiaoge
Cai, Qingqing
Zhang, Na
Qin, Xiaoyue
Zhao, Yijing
Wei, Wenming
Jia, Yumeng
Wen, Yan
Zhang, Feng
author_facet Meng, Peilin
Cheng, Bolun
Pan, Chuyu
Liu, Li
Cheng, Shiqiang
Yang, Xuena
Chen, Yujing
Li, Chun’e
Zhang, Huijie
Zhang, Zhen
Zhang, Jingxi
He, Dan
Shi, Sirong
Chu, Xiaoge
Cai, Qingqing
Zhang, Na
Qin, Xiaoyue
Zhao, Yijing
Wei, Wenming
Jia, Yumeng
Wen, Yan
Zhang, Feng
author_sort Meng, Peilin
collection PubMed
description There is a strong link between irritable bowel syndrome and brain volumes, yet, to date, research examining the mediators of this association has been little. Based on the phenotypic data of 15 248 participants from the UK Biobank, a two-stage mediation analysis was performed to assess the association among brain volumes, anxiety, and irritable bowel syndrome. In the first stage, we identified the candidate mediating role of anxiety for irritable bowel syndrome associated with brain volumes using regression models. Then, we quantified the magnitude of the mediation effects by evaluating the average causal-mediated effect and proportion of mediation through performing mediation analyses in the R package in the second stage. In the first stage, we identified the partly mediating role of anxiety in the association between irritable bowel syndrome and the volume of thalamus (P(left) = 1.16 × 10(−4), P(right) = 2.41 × 10(−4)), and grey matter (P(left) = 3.22 × 10(−2), P(right) = 1.18 × 10(−2)) in the VIIIa cerebellum. In the second stage, we observed that the proportion of the total effect of irritable bowel syndrome on volume of thalamus mediated by anxiety was 14.3% for the left region (β(Average causal-mediated effect) = −0.008, P(Average causal-mediated effect) = 0.004) and 14.6% for the right region (β(Average causal-mediated effect) = −0.007, P(Average causal-mediated effect) = 0.006). Anxiety mediated 30.8% for the left region (β(Average causal-mediated effect) = −0.013, P(Average causal-mediated effect) = 0.002) and 21.6% for the right region (β(Average causal-mediated effect) = −0.010, P(Average causal-mediated effect) x= 0.018) of the total effect of irritable bowel syndrome on the volume of grey matter in the VIIIa cerebellum. Our study revealed the indirect mediating role of anxiety in the association between irritable bowel syndrome and brain volumes, promoting our understanding of the functional mechanisms of irritable bowel syndrome and its related psychosocial factors.
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spelling pubmed-101165812023-04-21 Evaluating the role of anxiety on the association between irritable bowel syndrome and brain volumes: a mediation analysis in the UK Biobank cohort Meng, Peilin Cheng, Bolun Pan, Chuyu Liu, Li Cheng, Shiqiang Yang, Xuena Chen, Yujing Li, Chun’e Zhang, Huijie Zhang, Zhen Zhang, Jingxi He, Dan Shi, Sirong Chu, Xiaoge Cai, Qingqing Zhang, Na Qin, Xiaoyue Zhao, Yijing Wei, Wenming Jia, Yumeng Wen, Yan Zhang, Feng Brain Commun Original Article There is a strong link between irritable bowel syndrome and brain volumes, yet, to date, research examining the mediators of this association has been little. Based on the phenotypic data of 15 248 participants from the UK Biobank, a two-stage mediation analysis was performed to assess the association among brain volumes, anxiety, and irritable bowel syndrome. In the first stage, we identified the candidate mediating role of anxiety for irritable bowel syndrome associated with brain volumes using regression models. Then, we quantified the magnitude of the mediation effects by evaluating the average causal-mediated effect and proportion of mediation through performing mediation analyses in the R package in the second stage. In the first stage, we identified the partly mediating role of anxiety in the association between irritable bowel syndrome and the volume of thalamus (P(left) = 1.16 × 10(−4), P(right) = 2.41 × 10(−4)), and grey matter (P(left) = 3.22 × 10(−2), P(right) = 1.18 × 10(−2)) in the VIIIa cerebellum. In the second stage, we observed that the proportion of the total effect of irritable bowel syndrome on volume of thalamus mediated by anxiety was 14.3% for the left region (β(Average causal-mediated effect) = −0.008, P(Average causal-mediated effect) = 0.004) and 14.6% for the right region (β(Average causal-mediated effect) = −0.007, P(Average causal-mediated effect) = 0.006). Anxiety mediated 30.8% for the left region (β(Average causal-mediated effect) = −0.013, P(Average causal-mediated effect) = 0.002) and 21.6% for the right region (β(Average causal-mediated effect) = −0.010, P(Average causal-mediated effect) x= 0.018) of the total effect of irritable bowel syndrome on the volume of grey matter in the VIIIa cerebellum. Our study revealed the indirect mediating role of anxiety in the association between irritable bowel syndrome and brain volumes, promoting our understanding of the functional mechanisms of irritable bowel syndrome and its related psychosocial factors. Oxford University Press 2023-04-11 /pmc/articles/PMC10116581/ /pubmed/37091589 http://dx.doi.org/10.1093/braincomms/fcad116 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the Guarantors of Brain. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Meng, Peilin
Cheng, Bolun
Pan, Chuyu
Liu, Li
Cheng, Shiqiang
Yang, Xuena
Chen, Yujing
Li, Chun’e
Zhang, Huijie
Zhang, Zhen
Zhang, Jingxi
He, Dan
Shi, Sirong
Chu, Xiaoge
Cai, Qingqing
Zhang, Na
Qin, Xiaoyue
Zhao, Yijing
Wei, Wenming
Jia, Yumeng
Wen, Yan
Zhang, Feng
Evaluating the role of anxiety on the association between irritable bowel syndrome and brain volumes: a mediation analysis in the UK Biobank cohort
title Evaluating the role of anxiety on the association between irritable bowel syndrome and brain volumes: a mediation analysis in the UK Biobank cohort
title_full Evaluating the role of anxiety on the association between irritable bowel syndrome and brain volumes: a mediation analysis in the UK Biobank cohort
title_fullStr Evaluating the role of anxiety on the association between irritable bowel syndrome and brain volumes: a mediation analysis in the UK Biobank cohort
title_full_unstemmed Evaluating the role of anxiety on the association between irritable bowel syndrome and brain volumes: a mediation analysis in the UK Biobank cohort
title_short Evaluating the role of anxiety on the association between irritable bowel syndrome and brain volumes: a mediation analysis in the UK Biobank cohort
title_sort evaluating the role of anxiety on the association between irritable bowel syndrome and brain volumes: a mediation analysis in the uk biobank cohort
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10116581/
https://www.ncbi.nlm.nih.gov/pubmed/37091589
http://dx.doi.org/10.1093/braincomms/fcad116
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