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Perspectives on Usage of Functional Nanomaterials in Antimicrobial Therapy for Antibiotic-Resistant Bacterial Infections
[Image: see text] The clinical applications of nanotechnology are emerging as widely popular, particularly as a potential treatment approach for infectious diseases. Diseases associated with multiple drug-resistant organisms (MDROs) are a global concern of morbidity and mortality. The prevalence of...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10116640/ https://www.ncbi.nlm.nih.gov/pubmed/37091369 http://dx.doi.org/10.1021/acsomega.3c00110 |
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author | Karnwal, Arun Kumar, Gaurav Pant, Gaurav Hossain, Kaizar Ahmad, Akil Alshammari, Mohammed B. |
author_facet | Karnwal, Arun Kumar, Gaurav Pant, Gaurav Hossain, Kaizar Ahmad, Akil Alshammari, Mohammed B. |
author_sort | Karnwal, Arun |
collection | PubMed |
description | [Image: see text] The clinical applications of nanotechnology are emerging as widely popular, particularly as a potential treatment approach for infectious diseases. Diseases associated with multiple drug-resistant organisms (MDROs) are a global concern of morbidity and mortality. The prevalence of infections caused by antibiotic-resistant bacterial strains has increased the urgency associated with researching and developing novel bactericidal medicines or unorthodox methods capable of combating antimicrobial resistance. Nanomaterial-based treatments are promising for treating severe bacterial infections because they bypass antibiotic resistance mechanisms. Nanomaterial-based approaches, especially those that do not rely on small-molecule antimicrobials, display potential since they can bypass drug-resistant bacteria systems. Nanoparticles (NPs) are small enough to pass through the cell membranes of pathogenic bacteria and interfere with essential molecular pathways. They can also target biofilms and eliminate infections that have proven difficult to treat. In this review, we described the antibacterial mechanisms of NPs against bacteria and the parameters involved in targeting established antibiotic resistance and biofilms. Finally, yet importantly, we talked about NPs and the various ways they can be utilized, including as delivery methods, intrinsic antimicrobials, or a mixture. |
format | Online Article Text |
id | pubmed-10116640 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-101166402023-04-21 Perspectives on Usage of Functional Nanomaterials in Antimicrobial Therapy for Antibiotic-Resistant Bacterial Infections Karnwal, Arun Kumar, Gaurav Pant, Gaurav Hossain, Kaizar Ahmad, Akil Alshammari, Mohammed B. ACS Omega [Image: see text] The clinical applications of nanotechnology are emerging as widely popular, particularly as a potential treatment approach for infectious diseases. Diseases associated with multiple drug-resistant organisms (MDROs) are a global concern of morbidity and mortality. The prevalence of infections caused by antibiotic-resistant bacterial strains has increased the urgency associated with researching and developing novel bactericidal medicines or unorthodox methods capable of combating antimicrobial resistance. Nanomaterial-based treatments are promising for treating severe bacterial infections because they bypass antibiotic resistance mechanisms. Nanomaterial-based approaches, especially those that do not rely on small-molecule antimicrobials, display potential since they can bypass drug-resistant bacteria systems. Nanoparticles (NPs) are small enough to pass through the cell membranes of pathogenic bacteria and interfere with essential molecular pathways. They can also target biofilms and eliminate infections that have proven difficult to treat. In this review, we described the antibacterial mechanisms of NPs against bacteria and the parameters involved in targeting established antibiotic resistance and biofilms. Finally, yet importantly, we talked about NPs and the various ways they can be utilized, including as delivery methods, intrinsic antimicrobials, or a mixture. American Chemical Society 2023-04-06 /pmc/articles/PMC10116640/ /pubmed/37091369 http://dx.doi.org/10.1021/acsomega.3c00110 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Karnwal, Arun Kumar, Gaurav Pant, Gaurav Hossain, Kaizar Ahmad, Akil Alshammari, Mohammed B. Perspectives on Usage of Functional Nanomaterials in Antimicrobial Therapy for Antibiotic-Resistant Bacterial Infections |
title | Perspectives on
Usage of Functional Nanomaterials
in Antimicrobial Therapy for Antibiotic-Resistant Bacterial Infections |
title_full | Perspectives on
Usage of Functional Nanomaterials
in Antimicrobial Therapy for Antibiotic-Resistant Bacterial Infections |
title_fullStr | Perspectives on
Usage of Functional Nanomaterials
in Antimicrobial Therapy for Antibiotic-Resistant Bacterial Infections |
title_full_unstemmed | Perspectives on
Usage of Functional Nanomaterials
in Antimicrobial Therapy for Antibiotic-Resistant Bacterial Infections |
title_short | Perspectives on
Usage of Functional Nanomaterials
in Antimicrobial Therapy for Antibiotic-Resistant Bacterial Infections |
title_sort | perspectives on
usage of functional nanomaterials
in antimicrobial therapy for antibiotic-resistant bacterial infections |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10116640/ https://www.ncbi.nlm.nih.gov/pubmed/37091369 http://dx.doi.org/10.1021/acsomega.3c00110 |
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