Cargando…

Brassicasterol inhibits hepatitis B virus-associated hepatocellular carcinoma development via suppression of AKT signaling pathway

BACKGROUND: Hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) does not respond well to current treatment options like sorafenib, and there is an urgent need for developing therapeutical strategies for HBV + HCC. Brassicasterol has previously shown anti-cancer and anti-viral activitie...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zeng, Jindi, Wu, Jiancheng, Pang, Shuijiao, Wang, Feifei, Yu, Xin, Zhang, Shouhua, Zeng, Junquan, Yan, Jinlong, Lian, Jianping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10116783/ https://www.ncbi.nlm.nih.gov/pubmed/37081537 http://dx.doi.org/10.1186/s13027-023-00502-1

Ejemplares similares

Hepatitis B virus induces sorafenib resistance in liver cancer via upregulation of cIAP2 expression
por: Zhang, Shouhua, et al.
Publicado: (2021)

Brassicasterol from Edible Aquacultural Hippocampus abdominalis Exerts an Anti-Cancer Effect by Dual-Targeting AKT and AR Signaling in Prostate Cancer
por: Xu, Yinzhu, et al.
Publicado: (2020)

Sterol Lipid Metabolism in Down Syndrome Revisited: Down Syndrome Is Associated with a Selective Reduction in Serum Brassicasterol Levels
por: Tansley, Gavin, et al.
Publicado: (2012)

Brassicasterol with Dual Anti-Infective Properties against HSV-1 and Mycobacterium tuberculosis, and Cardiovascular Protective Effect: Nonclinical In Vitro and In Silico Assessments
por: Hassan, Sherif T. S.
Publicado: (2020)

Colon Cancer Cell Secretes EGF to Promote M2 Polarization of TAM Through EGFR/PI3K/AKT/mTOR Pathway
por: Lian, Guanghui, et al.
Publicado: (2019)

The Yunnan national medicine Maytenus compound inhibits the proliferation of hepatocellular carcinoma (HCC) by suppressing the activation of the EGFR-PI3K-AKT signaling pathway
por: Zhao, Wen-Tao, et al.
Publicado: (2021)

MST4 inhibits human hepatocellular carcinoma cell proliferation and induces cell cycle arrest via suppression of PI3K/AKT pathway
por: Hao, Wei-Chao, et al.
Publicado: (2020)

SERPINA11 Inhibits Metastasis in Hepatocellular Carcinoma by Suppressing MEK/ERK Signaling Pathway
por: Song, Ye, et al.
Publicado: (2021)

LINC01554-Mediated Glucose Metabolism Reprogramming Suppresses Tumorigenicity in Hepatocellular Carcinoma via Downregulating PKM2 Expression and Inhibiting Akt/mTOR Signaling Pathway
por: Zheng, Yin-Li, et al.
Publicado: (2019)

Targeting TF-AKT/ERK-EGFR Pathway Suppresses the Growth of Hepatocellular Carcinoma
por: Huang, Shan-Zhou, et al.
Publicado: (2019)

PCDH10 gene inhibits cell proliferation and induces cell apoptosis by inhibiting the PI3K/Akt signaling pathway in hepatocellular carcinoma cells
por: Ye, Mingxin, et al.
Publicado: (2017)

Cavin3 Suppresses Breast Cancer Metastasis via Inhibiting AKT Pathway
por: An, Xin, et al.
Publicado: (2020)

Inhibition of Hepatic Stellate Cell Activation Suppresses Tumorigenicity of Hepatocellular Carcinoma in Mice
por: Kang, Min-Jung, et al.
Publicado: (2021)

Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma in Rats by Inhibiting PI3K-AKT-NF-κB Pathway
por: Zhang, Cui-Li, et al.
Publicado: (2015)

Celastrol delays hepatic steatosis and carcinogenesis in a rapid AKT/c-Met-transfected hepatocellular carcinoma model via suppressing fatty acid synthase expression and AKT/ERK phosphorylation
por: Hu, Junjie, et al.
Publicado: (2018)

Daucosterol Inhibits the Proliferation, Migration, and Invasion of Hepatocellular Carcinoma Cells via Wnt/β-Catenin Signaling
por: Zeng, Junquan, et al.
Publicado: (2017)

Eriodictyol Suppresses Gastric Cancer Cells via Inhibition of PI3K/AKT Pathway
por: Shan, Hui, et al.
Publicado: (2022)

Heat shock protein 20 suppresses breast carcinogenesis by inhibiting the MAPK and AKT signaling pathways
por: Yang, Yinxi, et al.
Publicado: (2022)

Hedyotis diffusa Willd. Suppresses Hepatocellular Carcinoma via Downregulating AKT/mTOR Pathways
por: Huang, Lingli, et al.
Publicado: (2021)

Ropivacaine suppresses tumor biological characteristics of human hepatocellular carcinoma via inhibiting IGF-1R/PI3K/AKT/mTOR signaling axis
por: Zhang, Runze, et al.
Publicado: (2021)

Inhibition of MMP-2 Expression Enhances the Antitumor Effect of Sorafenib in Hepatocellular Carcinoma by Suppressing the PI3K/AKT/mTOR Pathway
por: Tan, Wenliang, et al.
Publicado: (2017)

BCL6B suppresses proliferation and migration of colorectal carcinoma cells through inhibition of the PI3K/AKT signaling pathway
por: Gu, Yue, et al.
Publicado: (2018)

Metformin Inhibit Cervical Cancer Migration by Suppressing the FAK/Akt Signaling Pathway
por: Hakimee, Henna, et al.
Publicado: (2019)

Biejiajian Pill Inhibits Carcinogenesis and Metastasis via the Akt/GSK-3β/Snail Signaling Pathway in Hepatocellular Carcinoma
por: Sun, Jialing, et al.
Publicado: (2021)

Curcumin in Combination With Omacetaxine Suppress Lymphoma Cell Growth, Migration, Invasion, and Angiogenesis via Inhibition of VEGF/Akt Signaling Pathway
por: Zhang, Yu, et al.
Publicado: (2021)

Anhydroicaritin suppresses tumor progression via the PI3K/AKT signaling pathway in hepatocellular carcinoma
por: Wang, Houhong, et al.
Publicado: (2023)

CLCA4 inhibits cell proliferation and invasion of hepatocellular carcinoma by suppressing epithelial-mesenchymal transition via PI3K/AKT signaling
por: Liu, Zhao, et al.
Publicado: (2018)

Suppression of Heterogeneous Nuclear Ribonucleoprotein C Inhibit Hepatocellular Carcinoma Proliferation, Migration, and Invasion via Ras/MAPK Signaling Pathway
por: Hu, Jiejun, et al.
Publicado: (2021)

Upregulation of miR-520c-3p via hepatitis B virus drives hepatocellular migration and invasion by the PTEN/AKT/NF-κB axis
por: Liu, Yang, et al.
Publicado: (2022)

Inhibition of squalene epoxidase linking with PI3K/AKT signaling pathway suppresses endometrial cancer
por: Ma, Liangjian, et al.
Publicado: (2023)

Integrative Analysis of Metallothioneins Identifies MT1H as Candidate Prognostic Biomarker in Hepatocellular Carcinoma
por: Zhang, Feng, et al.
Publicado: (2021)

Inhibition of PI3K/Akt signaling suppresses epithelial-to-mesenchymal transition in hepatocellular carcinoma through the Snail/GSK-3/beta-catenin pathway
por: Lee, Seulki, et al.
Publicado: (2020)

miR-30b-3p Inhibits Proliferation and Invasion of Hepatocellular Carcinoma Cells via Suppressing PI3K/Akt Pathway
por: Gao, Dongkai, et al.
Publicado: (2019)

WM130 preferentially inhibits hepatic cancer stem-like cells by suppressing AKT/GSK3β/β-catenin signaling pathway
por: Ni, Chen-Xu, et al.
Publicado: (2016)

Autophagic Inhibition of Caveolin-1 by Compound Phyllanthus urinaria L. Activates Ubiquitination and Proteasome Degradation of β-catenin to Suppress Metastasis of Hepatitis B-Associated Hepatocellular Carcinoma
por: Huang, Danping, et al.
Publicado: (2021)

Knockdown of OCT4 suppresses the growth and invasion of pancreatic cancer cells through inhibition of the AKT pathway
por: LIN, HAI, et al.
Publicado: (2014)

LBH589 Inhibits proliferation and metastasis of hepatocellular carcinoma via inhibition of gankyrin/stat3/akt pathway
por: Song, Xuan, et al.
Publicado: (2013)

Baicalin inhibits growth and induces apoptosis of human osteosarcoma cells by suppressing the AKT pathway
por: Liu, Yu, et al.
Publicado: (2019)

Zileuton suppresses cholangiocarcinoma cell proliferation and migration through inhibition of the Akt signaling pathway
por: Khophai, Sasikamon, et al.
Publicado: (2018)

Pterostilbene inhibits gallbladder cancer progression by suppressing the PI3K/Akt pathway
por: Tong, Chenhao, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_holkdedo7kmb357qs8noau4909