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Application and development of fecal microbiota transplantation in the treatment of gastrointestinal and metabolic diseases: A review

Fecal microbiota transplantation (FMT) restores a balanced intestinal flora, which helps to cure recurrent Clostridium difficile infections (RCDI). FMT has also been used to treat other gastrointestinal diseases, including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), and chronic...

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Autores principales: Mahmoudi, Hassan, Hossainpour, Hadi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117003/
https://www.ncbi.nlm.nih.gov/pubmed/36412458
http://dx.doi.org/10.4103/sjg.sjg_131_22
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author Mahmoudi, Hassan
Hossainpour, Hadi
author_facet Mahmoudi, Hassan
Hossainpour, Hadi
author_sort Mahmoudi, Hassan
collection PubMed
description Fecal microbiota transplantation (FMT) restores a balanced intestinal flora, which helps to cure recurrent Clostridium difficile infections (RCDI). FMT has also been used to treat other gastrointestinal diseases, including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), and chronic constipation, as well as a variety of non-GI disorders. The purpose of this review is to discuss gut microbiota and FMT treatment of GI and non-GI diseases. An imbalanced gut microbiota is known to predispose one to Clostridium difficile infections (CDI), IBD, and IBS. However, the complex role of the gut microbiota in maintaining health is a newer concept that is being increasingly studied. The microbiome plays a major role in cellular immunity and metabolism and has been implicated in the pathogenesis of non-GI autoimmune diseases, chronic fatigue syndrome, obesity, and even some neuropsychiatric disorders. Many recent studies have reported that viral gastroenteritis can affect intestinal epithelial cells, and SARS-CoV-2 virus has been identified in the stool of infected patients. FMT is a highly effective cure for RCDI, but a better understanding of the gut microbiota in maintaining health and controlled studies of FMT in a variety of conditions are needed before FMT can be accepted and used clinically.
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spelling pubmed-101170032023-04-21 Application and development of fecal microbiota transplantation in the treatment of gastrointestinal and metabolic diseases: A review Mahmoudi, Hassan Hossainpour, Hadi Saudi J Gastroenterol Review Article Fecal microbiota transplantation (FMT) restores a balanced intestinal flora, which helps to cure recurrent Clostridium difficile infections (RCDI). FMT has also been used to treat other gastrointestinal diseases, including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), and chronic constipation, as well as a variety of non-GI disorders. The purpose of this review is to discuss gut microbiota and FMT treatment of GI and non-GI diseases. An imbalanced gut microbiota is known to predispose one to Clostridium difficile infections (CDI), IBD, and IBS. However, the complex role of the gut microbiota in maintaining health is a newer concept that is being increasingly studied. The microbiome plays a major role in cellular immunity and metabolism and has been implicated in the pathogenesis of non-GI autoimmune diseases, chronic fatigue syndrome, obesity, and even some neuropsychiatric disorders. Many recent studies have reported that viral gastroenteritis can affect intestinal epithelial cells, and SARS-CoV-2 virus has been identified in the stool of infected patients. FMT is a highly effective cure for RCDI, but a better understanding of the gut microbiota in maintaining health and controlled studies of FMT in a variety of conditions are needed before FMT can be accepted and used clinically. Wolters Kluwer - Medknow 2022-11-14 /pmc/articles/PMC10117003/ /pubmed/36412458 http://dx.doi.org/10.4103/sjg.sjg_131_22 Text en Copyright: © 2022 Saudi Journal of Gastroenterology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Mahmoudi, Hassan
Hossainpour, Hadi
Application and development of fecal microbiota transplantation in the treatment of gastrointestinal and metabolic diseases: A review
title Application and development of fecal microbiota transplantation in the treatment of gastrointestinal and metabolic diseases: A review
title_full Application and development of fecal microbiota transplantation in the treatment of gastrointestinal and metabolic diseases: A review
title_fullStr Application and development of fecal microbiota transplantation in the treatment of gastrointestinal and metabolic diseases: A review
title_full_unstemmed Application and development of fecal microbiota transplantation in the treatment of gastrointestinal and metabolic diseases: A review
title_short Application and development of fecal microbiota transplantation in the treatment of gastrointestinal and metabolic diseases: A review
title_sort application and development of fecal microbiota transplantation in the treatment of gastrointestinal and metabolic diseases: a review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117003/
https://www.ncbi.nlm.nih.gov/pubmed/36412458
http://dx.doi.org/10.4103/sjg.sjg_131_22
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