Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation

Activating the macrophage NLRP3 inflammasome can promote excessive inflammation with severe cell and tissue damage and organ dysfunction. Here, we show that pharmacological or genetic inhibition of pyruvate dehydrogenase kinase (PDHK) significantly attenuates NLRP3 inflammasome activation in murine...

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Detalles Bibliográficos
Autores principales: Meyers, Allison K., Wang, Zhan, Han, Wenzheng, Zhao, Qingxia, Zabalawi, Manal, Duan, Likun, Liu, Juan, Zhang, Qianyi, Manne, Rajesh K., Lorenzo, Felipe, Quinn, Matthew A., Song, Qianqian, Fan, Daping, Lin, Hui-Kuan, Furdui, Cristina M., Locasale, Jason W., McCall, Charles E., Zhu, Xuewei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117036/
https://www.ncbi.nlm.nih.gov/pubmed/36640341
http://dx.doi.org/10.1016/j.celrep.2022.111941

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