Efficient generation of lower induced motor neurons by coupling Ngn2 expression with developmental cues

Human pluripotent stem cells (hPSCs) are a powerful tool for disease modeling of hard-to-access tissues (such as the brain). Current protocols either direct neuronal differentiation with small molecules or use transcription-factor-mediated programming. In this study, we couple overexpression of tran...

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Detalles Bibliográficos
Autores principales: Limone, Francesco, Juan, Irune Guerra San, Mitchell, Jana M., Smith, Janell L.M., Raghunathan, Kavya, Meyer, Daniel, Ghosh, Sulagna Dia, Couto, Alexander, Klim, Joseph R., Joseph, Brian J., Gold, John, Mello, Curtis J., Nemesh, James, Smith, Brittany M., Verhage, Matthijs, McCarroll, Steven A., Pietiläinen, Olli, Nehme, Ralda, Eggan, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117176/
https://www.ncbi.nlm.nih.gov/pubmed/36596304
http://dx.doi.org/10.1016/j.celrep.2022.111896

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