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The effectiveness of locally-prepared peritoneal dialysate in the management of children with acute kidney injury in a south-east Nigerian tertiary hospital
BACKGROUND: Peritoneal dialysis (PD) is the preferred mode of renal replacement therapy (RRT) in children with acute kidney injury (AKI). The gold standard remains the use of commercially-prepared PD fluid. In resource-poor nations, its availability and affordability remain a challenge. AIM: This st...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Makerere Medical School
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117520/ https://www.ncbi.nlm.nih.gov/pubmed/37092055 http://dx.doi.org/10.4314/ahs.v22i4.74 |
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author | Mbanefo, Ngozi R Uwaezuoke, Samuel N Chikani, Ugo N Bisi-Onyemaechi, Ada I Muoneke, Uzoamaka V Odetunde, Odutola I Okafor, Henrietta U |
author_facet | Mbanefo, Ngozi R Uwaezuoke, Samuel N Chikani, Ugo N Bisi-Onyemaechi, Ada I Muoneke, Uzoamaka V Odetunde, Odutola I Okafor, Henrietta U |
author_sort | Mbanefo, Ngozi R |
collection | PubMed |
description | BACKGROUND: Peritoneal dialysis (PD) is the preferred mode of renal replacement therapy (RRT) in children with acute kidney injury (AKI). The gold standard remains the use of commercially-prepared PD fluid. In resource-poor nations, its availability and affordability remain a challenge. AIM: This study aims to report the effectiveness of locally-prepared PD fluid in the management of AKI in a south-east Nigerian tertiary hospital. SUBJECTS AND METHODS: This was a retrospective study conducted at the paediatric ward of the University of Nigeria Teaching hospital, Enugu. The case records of 36 children seen over three years, diagnosed with AKI and requiring PD were reviewed. The retrieved information comprised biodata, aetiology of AKI, indications for PD, pre-and post-dialysis estimated glomerular filtration rate (eGFR) and patient outcomes. RESULTS: The children (20 males and 16 females) were aged 3 to 36 months with a mean age of 9.92 ± 6.29 months. The common aetiologies of AKI were septicemia (30.6%), hemolytic uremic syndrome (19.4%), and toxic nephropathy (16.7%). The frequent indications for PD were uremic encephalopathy (58.3%) and severe metabolic acidosis (38.8%). The pre-and post-dialysis mean urine flow rate was 0.16 + 0.13 and 2.77 + 0.56 ml/kg/hour respectively. The eGFR before PD, at discontinuation, and a week later was 6.06 + 2.87, 24.44 + 15.71 and 59.07 + 22.22 mls/min/1.73m2 respectively. CONCLUSION: PD with locally-prepared dialysate is safe, effective and a life-saving alternative in the management of AKI in children |
format | Online Article Text |
id | pubmed-10117520 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Makerere Medical School |
record_format | MEDLINE/PubMed |
spelling | pubmed-101175202023-04-21 The effectiveness of locally-prepared peritoneal dialysate in the management of children with acute kidney injury in a south-east Nigerian tertiary hospital Mbanefo, Ngozi R Uwaezuoke, Samuel N Chikani, Ugo N Bisi-Onyemaechi, Ada I Muoneke, Uzoamaka V Odetunde, Odutola I Okafor, Henrietta U Afr Health Sci Articles BACKGROUND: Peritoneal dialysis (PD) is the preferred mode of renal replacement therapy (RRT) in children with acute kidney injury (AKI). The gold standard remains the use of commercially-prepared PD fluid. In resource-poor nations, its availability and affordability remain a challenge. AIM: This study aims to report the effectiveness of locally-prepared PD fluid in the management of AKI in a south-east Nigerian tertiary hospital. SUBJECTS AND METHODS: This was a retrospective study conducted at the paediatric ward of the University of Nigeria Teaching hospital, Enugu. The case records of 36 children seen over three years, diagnosed with AKI and requiring PD were reviewed. The retrieved information comprised biodata, aetiology of AKI, indications for PD, pre-and post-dialysis estimated glomerular filtration rate (eGFR) and patient outcomes. RESULTS: The children (20 males and 16 females) were aged 3 to 36 months with a mean age of 9.92 ± 6.29 months. The common aetiologies of AKI were septicemia (30.6%), hemolytic uremic syndrome (19.4%), and toxic nephropathy (16.7%). The frequent indications for PD were uremic encephalopathy (58.3%) and severe metabolic acidosis (38.8%). The pre-and post-dialysis mean urine flow rate was 0.16 + 0.13 and 2.77 + 0.56 ml/kg/hour respectively. The eGFR before PD, at discontinuation, and a week later was 6.06 + 2.87, 24.44 + 15.71 and 59.07 + 22.22 mls/min/1.73m2 respectively. CONCLUSION: PD with locally-prepared dialysate is safe, effective and a life-saving alternative in the management of AKI in children Makerere Medical School 2022-12 /pmc/articles/PMC10117520/ /pubmed/37092055 http://dx.doi.org/10.4314/ahs.v22i4.74 Text en © 2022 Mbanefo NR et al. https://creativecommons.org/licenses/by/4.0/Licensee African Health Sciences. This is an Open Access article distributed under the terms of the Creative commons Attribution License (https://creativecommons.org/licenses/BY/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Mbanefo, Ngozi R Uwaezuoke, Samuel N Chikani, Ugo N Bisi-Onyemaechi, Ada I Muoneke, Uzoamaka V Odetunde, Odutola I Okafor, Henrietta U The effectiveness of locally-prepared peritoneal dialysate in the management of children with acute kidney injury in a south-east Nigerian tertiary hospital |
title | The effectiveness of locally-prepared peritoneal dialysate in the management of children with acute kidney injury in a south-east Nigerian tertiary hospital |
title_full | The effectiveness of locally-prepared peritoneal dialysate in the management of children with acute kidney injury in a south-east Nigerian tertiary hospital |
title_fullStr | The effectiveness of locally-prepared peritoneal dialysate in the management of children with acute kidney injury in a south-east Nigerian tertiary hospital |
title_full_unstemmed | The effectiveness of locally-prepared peritoneal dialysate in the management of children with acute kidney injury in a south-east Nigerian tertiary hospital |
title_short | The effectiveness of locally-prepared peritoneal dialysate in the management of children with acute kidney injury in a south-east Nigerian tertiary hospital |
title_sort | effectiveness of locally-prepared peritoneal dialysate in the management of children with acute kidney injury in a south-east nigerian tertiary hospital |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117520/ https://www.ncbi.nlm.nih.gov/pubmed/37092055 http://dx.doi.org/10.4314/ahs.v22i4.74 |
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