APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge

The E4 allele of Apolipoprotein E (APOE) is associated with both metabolic dysfunction and a heightened proinflammatory response: two findings that may be intrinsically linked through the concept of immunometabolism. Here, we combined bulk, single-cell, and spatial transcriptomics with cell-specific...

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Detalles Bibliográficos
Autores principales: Lee, Sangderk, Devanney, Nicholas A., Golden, Lesley R., Smith, Cathryn T., Schwartz, James L., Walsh, Adeline E., Clarke, Harrison A., Goulding, Danielle S., Allenger, Elizabeth J., Morillo-Segovia, Gabriella, Friday, Cassi M., Gorman, Amy A., Hawkinson, Tara R., MacLean, Steven M., Williams, Holden C., Sun, Ramon C., Morganti, Josh M., Johnson, Lance A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117631/
https://www.ncbi.nlm.nih.gov/pubmed/36871219
http://dx.doi.org/10.1016/j.celrep.2023.112196

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