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The pharmacology and mechanisms of platycodin D, an active triterpenoid saponin from Platycodon grandiflorus
Chinese doctors widely prescribed Platycodon grandiflorus A. DC. (PG) to treat lung carbuncles in ancient China. Modern clinical experiences have demonstrated that PG plays a crucial role in treating chronic pharyngitis, plum pneumonia, pneumoconiosis, acute and chronic laryngitis, and so forth. Add...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117678/ https://www.ncbi.nlm.nih.gov/pubmed/37089949 http://dx.doi.org/10.3389/fphar.2023.1148853 |
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author | Xie, Long Zhao, Yu-Xin Zheng, Yu Li, Xiao-Fang |
author_facet | Xie, Long Zhao, Yu-Xin Zheng, Yu Li, Xiao-Fang |
author_sort | Xie, Long |
collection | PubMed |
description | Chinese doctors widely prescribed Platycodon grandiflorus A. DC. (PG) to treat lung carbuncles in ancient China. Modern clinical experiences have demonstrated that PG plays a crucial role in treating chronic pharyngitis, plum pneumonia, pneumoconiosis, acute and chronic laryngitis, and so forth. Additionally, PG is a food with a long history in China, Japan, and Korea. Furthermore, Platycodin D (PLD), an oleanane-type triterpenoid saponin, is one of the active substances in PG. PLD has been revealed to have anti-inflammatory, anti-viral, anti-oxidation, anti-obesity, anticoagulant, spermicidal, anti-tumor etc., activities. And the mechanism of the effects draws lots of attention, with various signaling pathways involved in these processes. Additionally, research on PLD’s pharmacokinetics and extraction processes is under study. The bioavailability of PLD could be improved by being prescribed with Glycyrrhiza uralensis Fisch. or by creating a new dosage form. PLD has been recently considered to have the potential to be a solubilizer or an immunologic adjuvant. Meanwhile, PLD was discovered to have hemolytic activity correlated. PLD has broad application prospects and reveals practical pharmacological activities in pre-clinical research. The authors believe that these activities of PLD contribute to the efficacy of PG. What is apparent is that the clinical translation of PLD still has a long way to go. With the help of modern technology, the scope of clinical applications of PLD is probable to be expanded from traditional applications to new fields. |
format | Online Article Text |
id | pubmed-10117678 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101176782023-04-21 The pharmacology and mechanisms of platycodin D, an active triterpenoid saponin from Platycodon grandiflorus Xie, Long Zhao, Yu-Xin Zheng, Yu Li, Xiao-Fang Front Pharmacol Pharmacology Chinese doctors widely prescribed Platycodon grandiflorus A. DC. (PG) to treat lung carbuncles in ancient China. Modern clinical experiences have demonstrated that PG plays a crucial role in treating chronic pharyngitis, plum pneumonia, pneumoconiosis, acute and chronic laryngitis, and so forth. Additionally, PG is a food with a long history in China, Japan, and Korea. Furthermore, Platycodin D (PLD), an oleanane-type triterpenoid saponin, is one of the active substances in PG. PLD has been revealed to have anti-inflammatory, anti-viral, anti-oxidation, anti-obesity, anticoagulant, spermicidal, anti-tumor etc., activities. And the mechanism of the effects draws lots of attention, with various signaling pathways involved in these processes. Additionally, research on PLD’s pharmacokinetics and extraction processes is under study. The bioavailability of PLD could be improved by being prescribed with Glycyrrhiza uralensis Fisch. or by creating a new dosage form. PLD has been recently considered to have the potential to be a solubilizer or an immunologic adjuvant. Meanwhile, PLD was discovered to have hemolytic activity correlated. PLD has broad application prospects and reveals practical pharmacological activities in pre-clinical research. The authors believe that these activities of PLD contribute to the efficacy of PG. What is apparent is that the clinical translation of PLD still has a long way to go. With the help of modern technology, the scope of clinical applications of PLD is probable to be expanded from traditional applications to new fields. Frontiers Media S.A. 2023-04-06 /pmc/articles/PMC10117678/ /pubmed/37089949 http://dx.doi.org/10.3389/fphar.2023.1148853 Text en Copyright © 2023 Xie, Zhao, Zheng and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Xie, Long Zhao, Yu-Xin Zheng, Yu Li, Xiao-Fang The pharmacology and mechanisms of platycodin D, an active triterpenoid saponin from Platycodon grandiflorus |
title | The pharmacology and mechanisms of platycodin D, an active triterpenoid saponin from Platycodon grandiflorus
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title_full | The pharmacology and mechanisms of platycodin D, an active triterpenoid saponin from Platycodon grandiflorus
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title_fullStr | The pharmacology and mechanisms of platycodin D, an active triterpenoid saponin from Platycodon grandiflorus
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title_full_unstemmed | The pharmacology and mechanisms of platycodin D, an active triterpenoid saponin from Platycodon grandiflorus
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title_short | The pharmacology and mechanisms of platycodin D, an active triterpenoid saponin from Platycodon grandiflorus
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title_sort | pharmacology and mechanisms of platycodin d, an active triterpenoid saponin from platycodon grandiflorus |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117678/ https://www.ncbi.nlm.nih.gov/pubmed/37089949 http://dx.doi.org/10.3389/fphar.2023.1148853 |
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