Cargando…

The pharmacology and mechanisms of platycodin D, an active triterpenoid saponin from Platycodon grandiflorus

Chinese doctors widely prescribed Platycodon grandiflorus A. DC. (PG) to treat lung carbuncles in ancient China. Modern clinical experiences have demonstrated that PG plays a crucial role in treating chronic pharyngitis, plum pneumonia, pneumoconiosis, acute and chronic laryngitis, and so forth. Add...

Descripción completa

Detalles Bibliográficos
Autores principales: Xie, Long, Zhao, Yu-Xin, Zheng, Yu, Li, Xiao-Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117678/
https://www.ncbi.nlm.nih.gov/pubmed/37089949
http://dx.doi.org/10.3389/fphar.2023.1148853
_version_ 1785028643733372928
author Xie, Long
Zhao, Yu-Xin
Zheng, Yu
Li, Xiao-Fang
author_facet Xie, Long
Zhao, Yu-Xin
Zheng, Yu
Li, Xiao-Fang
author_sort Xie, Long
collection PubMed
description Chinese doctors widely prescribed Platycodon grandiflorus A. DC. (PG) to treat lung carbuncles in ancient China. Modern clinical experiences have demonstrated that PG plays a crucial role in treating chronic pharyngitis, plum pneumonia, pneumoconiosis, acute and chronic laryngitis, and so forth. Additionally, PG is a food with a long history in China, Japan, and Korea. Furthermore, Platycodin D (PLD), an oleanane-type triterpenoid saponin, is one of the active substances in PG. PLD has been revealed to have anti-inflammatory, anti-viral, anti-oxidation, anti-obesity, anticoagulant, spermicidal, anti-tumor etc., activities. And the mechanism of the effects draws lots of attention, with various signaling pathways involved in these processes. Additionally, research on PLD’s pharmacokinetics and extraction processes is under study. The bioavailability of PLD could be improved by being prescribed with Glycyrrhiza uralensis Fisch. or by creating a new dosage form. PLD has been recently considered to have the potential to be a solubilizer or an immunologic adjuvant. Meanwhile, PLD was discovered to have hemolytic activity correlated. PLD has broad application prospects and reveals practical pharmacological activities in pre-clinical research. The authors believe that these activities of PLD contribute to the efficacy of PG. What is apparent is that the clinical translation of PLD still has a long way to go. With the help of modern technology, the scope of clinical applications of PLD is probable to be expanded from traditional applications to new fields.
format Online
Article
Text
id pubmed-10117678
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-101176782023-04-21 The pharmacology and mechanisms of platycodin D, an active triterpenoid saponin from Platycodon grandiflorus Xie, Long Zhao, Yu-Xin Zheng, Yu Li, Xiao-Fang Front Pharmacol Pharmacology Chinese doctors widely prescribed Platycodon grandiflorus A. DC. (PG) to treat lung carbuncles in ancient China. Modern clinical experiences have demonstrated that PG plays a crucial role in treating chronic pharyngitis, plum pneumonia, pneumoconiosis, acute and chronic laryngitis, and so forth. Additionally, PG is a food with a long history in China, Japan, and Korea. Furthermore, Platycodin D (PLD), an oleanane-type triterpenoid saponin, is one of the active substances in PG. PLD has been revealed to have anti-inflammatory, anti-viral, anti-oxidation, anti-obesity, anticoagulant, spermicidal, anti-tumor etc., activities. And the mechanism of the effects draws lots of attention, with various signaling pathways involved in these processes. Additionally, research on PLD’s pharmacokinetics and extraction processes is under study. The bioavailability of PLD could be improved by being prescribed with Glycyrrhiza uralensis Fisch. or by creating a new dosage form. PLD has been recently considered to have the potential to be a solubilizer or an immunologic adjuvant. Meanwhile, PLD was discovered to have hemolytic activity correlated. PLD has broad application prospects and reveals practical pharmacological activities in pre-clinical research. The authors believe that these activities of PLD contribute to the efficacy of PG. What is apparent is that the clinical translation of PLD still has a long way to go. With the help of modern technology, the scope of clinical applications of PLD is probable to be expanded from traditional applications to new fields. Frontiers Media S.A. 2023-04-06 /pmc/articles/PMC10117678/ /pubmed/37089949 http://dx.doi.org/10.3389/fphar.2023.1148853 Text en Copyright © 2023 Xie, Zhao, Zheng and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Xie, Long
Zhao, Yu-Xin
Zheng, Yu
Li, Xiao-Fang
The pharmacology and mechanisms of platycodin D, an active triterpenoid saponin from Platycodon grandiflorus
title The pharmacology and mechanisms of platycodin D, an active triterpenoid saponin from Platycodon grandiflorus
title_full The pharmacology and mechanisms of platycodin D, an active triterpenoid saponin from Platycodon grandiflorus
title_fullStr The pharmacology and mechanisms of platycodin D, an active triterpenoid saponin from Platycodon grandiflorus
title_full_unstemmed The pharmacology and mechanisms of platycodin D, an active triterpenoid saponin from Platycodon grandiflorus
title_short The pharmacology and mechanisms of platycodin D, an active triterpenoid saponin from Platycodon grandiflorus
title_sort pharmacology and mechanisms of platycodin d, an active triterpenoid saponin from platycodon grandiflorus
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117678/
https://www.ncbi.nlm.nih.gov/pubmed/37089949
http://dx.doi.org/10.3389/fphar.2023.1148853
work_keys_str_mv AT xielong thepharmacologyandmechanismsofplatycodindanactivetriterpenoidsaponinfromplatycodongrandiflorus
AT zhaoyuxin thepharmacologyandmechanismsofplatycodindanactivetriterpenoidsaponinfromplatycodongrandiflorus
AT zhengyu thepharmacologyandmechanismsofplatycodindanactivetriterpenoidsaponinfromplatycodongrandiflorus
AT lixiaofang thepharmacologyandmechanismsofplatycodindanactivetriterpenoidsaponinfromplatycodongrandiflorus
AT xielong pharmacologyandmechanismsofplatycodindanactivetriterpenoidsaponinfromplatycodongrandiflorus
AT zhaoyuxin pharmacologyandmechanismsofplatycodindanactivetriterpenoidsaponinfromplatycodongrandiflorus
AT zhengyu pharmacologyandmechanismsofplatycodindanactivetriterpenoidsaponinfromplatycodongrandiflorus
AT lixiaofang pharmacologyandmechanismsofplatycodindanactivetriterpenoidsaponinfromplatycodongrandiflorus