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Roles of DNA damage in renal tubular epithelial cells injury

The prevalence of renal diseases including acute kidney injury (AKI) and chronic kidney disease (CKD) is increasing worldwide. However, the pathogenesis of most renal diseases is still unclear and effective treatments are still lacking. DNA damage and the related DNA damage response (DDR) have been...

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Autores principales: Wang, Peipei, Ouyang, Jing, Jia, Zhanjun, Zhang, Aihua, Yang, Yunwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117683/
https://www.ncbi.nlm.nih.gov/pubmed/37089416
http://dx.doi.org/10.3389/fphys.2023.1162546
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author Wang, Peipei
Ouyang, Jing
Jia, Zhanjun
Zhang, Aihua
Yang, Yunwen
author_facet Wang, Peipei
Ouyang, Jing
Jia, Zhanjun
Zhang, Aihua
Yang, Yunwen
author_sort Wang, Peipei
collection PubMed
description The prevalence of renal diseases including acute kidney injury (AKI) and chronic kidney disease (CKD) is increasing worldwide. However, the pathogenesis of most renal diseases is still unclear and effective treatments are still lacking. DNA damage and the related DNA damage response (DDR) have been confirmed as common pathogenesis of acute kidney injury and chronic kidney disease. Reactive oxygen species (ROS) induced DNA damage is one of the most common types of DNA damage involved in the pathogenesis of acute kidney injury and chronic kidney disease. In recent years, several developments have been made in the field of DNA damage. Herein, we review the roles and developments of DNA damage and DNA damage response in renal tubular epithelial cell injury in acute kidney injury and chronic kidney disease. In this review, we conclude that focusing on DNA damage and DNA damage response may provide valuable diagnostic biomarkers and treatment strategies for renal diseases including acute kidney injury and chronic kidney disease.
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spelling pubmed-101176832023-04-21 Roles of DNA damage in renal tubular epithelial cells injury Wang, Peipei Ouyang, Jing Jia, Zhanjun Zhang, Aihua Yang, Yunwen Front Physiol Physiology The prevalence of renal diseases including acute kidney injury (AKI) and chronic kidney disease (CKD) is increasing worldwide. However, the pathogenesis of most renal diseases is still unclear and effective treatments are still lacking. DNA damage and the related DNA damage response (DDR) have been confirmed as common pathogenesis of acute kidney injury and chronic kidney disease. Reactive oxygen species (ROS) induced DNA damage is one of the most common types of DNA damage involved in the pathogenesis of acute kidney injury and chronic kidney disease. In recent years, several developments have been made in the field of DNA damage. Herein, we review the roles and developments of DNA damage and DNA damage response in renal tubular epithelial cell injury in acute kidney injury and chronic kidney disease. In this review, we conclude that focusing on DNA damage and DNA damage response may provide valuable diagnostic biomarkers and treatment strategies for renal diseases including acute kidney injury and chronic kidney disease. Frontiers Media S.A. 2023-04-06 /pmc/articles/PMC10117683/ /pubmed/37089416 http://dx.doi.org/10.3389/fphys.2023.1162546 Text en Copyright © 2023 Wang, Ouyang, Jia, Zhang and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Wang, Peipei
Ouyang, Jing
Jia, Zhanjun
Zhang, Aihua
Yang, Yunwen
Roles of DNA damage in renal tubular epithelial cells injury
title Roles of DNA damage in renal tubular epithelial cells injury
title_full Roles of DNA damage in renal tubular epithelial cells injury
title_fullStr Roles of DNA damage in renal tubular epithelial cells injury
title_full_unstemmed Roles of DNA damage in renal tubular epithelial cells injury
title_short Roles of DNA damage in renal tubular epithelial cells injury
title_sort roles of dna damage in renal tubular epithelial cells injury
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117683/
https://www.ncbi.nlm.nih.gov/pubmed/37089416
http://dx.doi.org/10.3389/fphys.2023.1162546
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