A Phase 1 Study of Oral Vitamin D(3) in Boys and Young Men With X-Linked Adrenoleukodystrophy

BACKGROUND AND OBJECTIVES: There are no therapies for preventing cerebral demyelination in X-linked adrenoleukodystrophy (ALD). Higher plasma vitamin D levels have been linked to lower risk of inflammatory brain lesions. We assessed the safety and pharmacokinetics of oral vitamin D dosing regimens i...

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Detalles Bibliográficos
Autores principales: Van Haren, Keith P., Cunanan, Kristen, Awani, Avni, Gu, Meng, Peña, Dalia, Chromik, Lindsay C., Považan, Michal, Rossi, Nicole C., Goodman, Jordan, Sundaram, Vandana, Winterbottom, Jennifer, Raymond, Gerald V., Cowan, Tina, Enns, Gregory M., Waubant, Emmanuelle, Steinman, Lawrence, Barker, Peter B., Spielman, Daniel, Fatemi, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117697/
https://www.ncbi.nlm.nih.gov/pubmed/37090939
http://dx.doi.org/10.1212/NXG.0000000000200061

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