Should we treat pediatric radiologically isolated syndrome? An 18-year follow-up case report

BACKGROUND: Radiologically isolated syndrome (RIS) describes asymptomatic individuals with incidental radiologic abnormalities suggestive of multiple sclerosis (MS). Much of RIS literature is about adult-onset cases. Treatment of RIS is controversial, especially in pediatric age, but early treatment...

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Detalles Bibliográficos
Autores principales: Barbuti, Elena, Nistri, Riccardo, Ianniello, Antonio, Pozzilli, Carlo, Ruggieri, Serena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117757/
https://www.ncbi.nlm.nih.gov/pubmed/37090972
http://dx.doi.org/10.3389/fneur.2023.1145260
Descripción
Sumario:BACKGROUND: Radiologically isolated syndrome (RIS) describes asymptomatic individuals with incidental radiologic abnormalities suggestive of multiple sclerosis (MS). Much of RIS literature is about adult-onset cases. Treatment of RIS is controversial, especially in pediatric age, but early treatment in selected patients might improve long-term outcomes. CASE PRESENTATION: We report a single RIS patient who followed up for 18 years in our MS center. At first, she was only monitored with follow-up MRIs. Then, as the lesion load increased, she was treated with a first-line disease-modifying treatment (DMT) reaching MRI stability. CONCLUSION: This report highlights how treatment can be an appropriate choice in pediatric forms of RIS.

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