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Characterizing viscoelastic properties of human melanoma tissue using Prony series

Melanoma is the most invasive and deadly skin cancer, which causes most of the deaths from skin cancer. It has been demonstrated that the mechanical properties of tumor tissue are significantly altered. However, data about characterizing the mechanical properties of in vivo melanoma tissue are extre...

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Autores principales: Park, Seungman, Chien, Anna L., Brown, Isabelle D., Chen, Jingchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117758/
https://www.ncbi.nlm.nih.gov/pubmed/37091343
http://dx.doi.org/10.3389/fbioe.2023.1162880
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author Park, Seungman
Chien, Anna L.
Brown, Isabelle D.
Chen, Jingchun
author_facet Park, Seungman
Chien, Anna L.
Brown, Isabelle D.
Chen, Jingchun
author_sort Park, Seungman
collection PubMed
description Melanoma is the most invasive and deadly skin cancer, which causes most of the deaths from skin cancer. It has been demonstrated that the mechanical properties of tumor tissue are significantly altered. However, data about characterizing the mechanical properties of in vivo melanoma tissue are extremely scarce. In addition, the viscoelastic or viscous properties of melanoma tissue are rarely reported. In this study, we measured and quantitated the viscoelastic properties of human melanoma tissues based on the stress relaxation test, using the indentation-based mechanical analyzer that we developed previously. The melanoma tissues from eight patients of different ages (57–95), genders (male and female patients), races (White and Asian), and sites (nose, arm, shoulder, and chest) were excised and tested. The results showed that the elastic property (i.e., shear modulus) of melanoma tissue was elevated compared to normal tissue, while the viscous property (i.e., relaxation time) was reduced. Moreover, the tissue thickness had a significant impact on the viscoelastic properties, probably due to the amount of the adipose layer. Our findings provide new insights into the role of the viscous and elastic properties of melanoma cell mechanics, which may be implicated in the disease state and progression.
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spelling pubmed-101177582023-04-21 Characterizing viscoelastic properties of human melanoma tissue using Prony series Park, Seungman Chien, Anna L. Brown, Isabelle D. Chen, Jingchun Front Bioeng Biotechnol Bioengineering and Biotechnology Melanoma is the most invasive and deadly skin cancer, which causes most of the deaths from skin cancer. It has been demonstrated that the mechanical properties of tumor tissue are significantly altered. However, data about characterizing the mechanical properties of in vivo melanoma tissue are extremely scarce. In addition, the viscoelastic or viscous properties of melanoma tissue are rarely reported. In this study, we measured and quantitated the viscoelastic properties of human melanoma tissues based on the stress relaxation test, using the indentation-based mechanical analyzer that we developed previously. The melanoma tissues from eight patients of different ages (57–95), genders (male and female patients), races (White and Asian), and sites (nose, arm, shoulder, and chest) were excised and tested. The results showed that the elastic property (i.e., shear modulus) of melanoma tissue was elevated compared to normal tissue, while the viscous property (i.e., relaxation time) was reduced. Moreover, the tissue thickness had a significant impact on the viscoelastic properties, probably due to the amount of the adipose layer. Our findings provide new insights into the role of the viscous and elastic properties of melanoma cell mechanics, which may be implicated in the disease state and progression. Frontiers Media S.A. 2023-04-06 /pmc/articles/PMC10117758/ /pubmed/37091343 http://dx.doi.org/10.3389/fbioe.2023.1162880 Text en Copyright © 2023 Park, Chien, Brown and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Park, Seungman
Chien, Anna L.
Brown, Isabelle D.
Chen, Jingchun
Characterizing viscoelastic properties of human melanoma tissue using Prony series
title Characterizing viscoelastic properties of human melanoma tissue using Prony series
title_full Characterizing viscoelastic properties of human melanoma tissue using Prony series
title_fullStr Characterizing viscoelastic properties of human melanoma tissue using Prony series
title_full_unstemmed Characterizing viscoelastic properties of human melanoma tissue using Prony series
title_short Characterizing viscoelastic properties of human melanoma tissue using Prony series
title_sort characterizing viscoelastic properties of human melanoma tissue using prony series
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117758/
https://www.ncbi.nlm.nih.gov/pubmed/37091343
http://dx.doi.org/10.3389/fbioe.2023.1162880
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