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Cell- and subcellular organelle-targeting nanoparticle-mediated breast cancer therapy
Breast cancer (BC) is the most prevalent malignant tumor, surpassing lung cancer as the most frequent malignancy in women. Drug resistance, metastasis, and immune escape are the major factors affecting patient survival and represent a huge challenge in BC treatment in clinic. The cell- and subcellul...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117787/ https://www.ncbi.nlm.nih.gov/pubmed/37089933 http://dx.doi.org/10.3389/fphar.2023.1180794 |
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author | Wei, Xue Yang, Ming |
author_facet | Wei, Xue Yang, Ming |
author_sort | Wei, Xue |
collection | PubMed |
description | Breast cancer (BC) is the most prevalent malignant tumor, surpassing lung cancer as the most frequent malignancy in women. Drug resistance, metastasis, and immune escape are the major factors affecting patient survival and represent a huge challenge in BC treatment in clinic. The cell- and subcellular organelle-targeting nanoparticles-mediated targeted BC therapy may be an effective modality for immune evasion, metastasis, and drug resistance. Nanocarriers, efficiently delivering small molecules and macromolecules, are used to target subcellular apparatuses with excellent targeting, controlled delivery, and fewer side effects. This study summarizes and critically analyzes the latest organic nanoparticle-mediated subcellular targeted therapeutic based on chemotherapy, gene therapy, immunotherapy, and combination therapy in detail, and discusses the challenges and opportunities of nanoparticle therapy. |
format | Online Article Text |
id | pubmed-10117787 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101177872023-04-21 Cell- and subcellular organelle-targeting nanoparticle-mediated breast cancer therapy Wei, Xue Yang, Ming Front Pharmacol Pharmacology Breast cancer (BC) is the most prevalent malignant tumor, surpassing lung cancer as the most frequent malignancy in women. Drug resistance, metastasis, and immune escape are the major factors affecting patient survival and represent a huge challenge in BC treatment in clinic. The cell- and subcellular organelle-targeting nanoparticles-mediated targeted BC therapy may be an effective modality for immune evasion, metastasis, and drug resistance. Nanocarriers, efficiently delivering small molecules and macromolecules, are used to target subcellular apparatuses with excellent targeting, controlled delivery, and fewer side effects. This study summarizes and critically analyzes the latest organic nanoparticle-mediated subcellular targeted therapeutic based on chemotherapy, gene therapy, immunotherapy, and combination therapy in detail, and discusses the challenges and opportunities of nanoparticle therapy. Frontiers Media S.A. 2023-04-06 /pmc/articles/PMC10117787/ /pubmed/37089933 http://dx.doi.org/10.3389/fphar.2023.1180794 Text en Copyright © 2023 Wei and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Wei, Xue Yang, Ming Cell- and subcellular organelle-targeting nanoparticle-mediated breast cancer therapy |
title | Cell- and subcellular organelle-targeting nanoparticle-mediated breast cancer therapy |
title_full | Cell- and subcellular organelle-targeting nanoparticle-mediated breast cancer therapy |
title_fullStr | Cell- and subcellular organelle-targeting nanoparticle-mediated breast cancer therapy |
title_full_unstemmed | Cell- and subcellular organelle-targeting nanoparticle-mediated breast cancer therapy |
title_short | Cell- and subcellular organelle-targeting nanoparticle-mediated breast cancer therapy |
title_sort | cell- and subcellular organelle-targeting nanoparticle-mediated breast cancer therapy |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117787/ https://www.ncbi.nlm.nih.gov/pubmed/37089933 http://dx.doi.org/10.3389/fphar.2023.1180794 |
work_keys_str_mv | AT weixue cellandsubcellularorganelletargetingnanoparticlemediatedbreastcancertherapy AT yangming cellandsubcellularorganelletargetingnanoparticlemediatedbreastcancertherapy |