Cargando…
New insights into autophagy in inflammatory subtypes of asthma
Asthma is a heterogeneous airway disease characterized by airway inflammation and hyperresponsiveness. Autophagy is a self-degrading process that helps maintain cellular homeostasis. Dysregulation of autophagy is involved in the pathogenesis of many diseases. In the context of asthma, autophagy has...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117973/ https://www.ncbi.nlm.nih.gov/pubmed/37090692 http://dx.doi.org/10.3389/fimmu.2023.1156086 |
_version_ | 1785028707109306368 |
---|---|
author | Dong, Hongna Yang, Wei Li, Wei Zhu, Simin Zhu, Ling Gao, Peng Hao, Yuqiu |
author_facet | Dong, Hongna Yang, Wei Li, Wei Zhu, Simin Zhu, Ling Gao, Peng Hao, Yuqiu |
author_sort | Dong, Hongna |
collection | PubMed |
description | Asthma is a heterogeneous airway disease characterized by airway inflammation and hyperresponsiveness. Autophagy is a self-degrading process that helps maintain cellular homeostasis. Dysregulation of autophagy is involved in the pathogenesis of many diseases. In the context of asthma, autophagy has been shown to be associated with inflammation, airway remodeling, and responsiveness to drug therapy. In-depth characterization of the role of autophagy in asthma can enhance the understanding of the pathogenesis, and provide a theoretical basis for the development of new biomarkers and targeted therapy for asthma. In this article, we focus on the relationship of autophagy and asthma, and discuss its implications for asthma pathogenesis and treatment. |
format | Online Article Text |
id | pubmed-10117973 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101179732023-04-21 New insights into autophagy in inflammatory subtypes of asthma Dong, Hongna Yang, Wei Li, Wei Zhu, Simin Zhu, Ling Gao, Peng Hao, Yuqiu Front Immunol Immunology Asthma is a heterogeneous airway disease characterized by airway inflammation and hyperresponsiveness. Autophagy is a self-degrading process that helps maintain cellular homeostasis. Dysregulation of autophagy is involved in the pathogenesis of many diseases. In the context of asthma, autophagy has been shown to be associated with inflammation, airway remodeling, and responsiveness to drug therapy. In-depth characterization of the role of autophagy in asthma can enhance the understanding of the pathogenesis, and provide a theoretical basis for the development of new biomarkers and targeted therapy for asthma. In this article, we focus on the relationship of autophagy and asthma, and discuss its implications for asthma pathogenesis and treatment. Frontiers Media S.A. 2023-04-06 /pmc/articles/PMC10117973/ /pubmed/37090692 http://dx.doi.org/10.3389/fimmu.2023.1156086 Text en Copyright © 2023 Dong, Yang, Li, Zhu, Zhu, Gao and Hao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Dong, Hongna Yang, Wei Li, Wei Zhu, Simin Zhu, Ling Gao, Peng Hao, Yuqiu New insights into autophagy in inflammatory subtypes of asthma |
title | New insights into autophagy in inflammatory subtypes of asthma |
title_full | New insights into autophagy in inflammatory subtypes of asthma |
title_fullStr | New insights into autophagy in inflammatory subtypes of asthma |
title_full_unstemmed | New insights into autophagy in inflammatory subtypes of asthma |
title_short | New insights into autophagy in inflammatory subtypes of asthma |
title_sort | new insights into autophagy in inflammatory subtypes of asthma |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117973/ https://www.ncbi.nlm.nih.gov/pubmed/37090692 http://dx.doi.org/10.3389/fimmu.2023.1156086 |
work_keys_str_mv | AT donghongna newinsightsintoautophagyininflammatorysubtypesofasthma AT yangwei newinsightsintoautophagyininflammatorysubtypesofasthma AT liwei newinsightsintoautophagyininflammatorysubtypesofasthma AT zhusimin newinsightsintoautophagyininflammatorysubtypesofasthma AT zhuling newinsightsintoautophagyininflammatorysubtypesofasthma AT gaopeng newinsightsintoautophagyininflammatorysubtypesofasthma AT haoyuqiu newinsightsintoautophagyininflammatorysubtypesofasthma |