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New insights into autophagy in inflammatory subtypes of asthma

Asthma is a heterogeneous airway disease characterized by airway inflammation and hyperresponsiveness. Autophagy is a self-degrading process that helps maintain cellular homeostasis. Dysregulation of autophagy is involved in the pathogenesis of many diseases. In the context of asthma, autophagy has...

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Autores principales: Dong, Hongna, Yang, Wei, Li, Wei, Zhu, Simin, Zhu, Ling, Gao, Peng, Hao, Yuqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117973/
https://www.ncbi.nlm.nih.gov/pubmed/37090692
http://dx.doi.org/10.3389/fimmu.2023.1156086
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author Dong, Hongna
Yang, Wei
Li, Wei
Zhu, Simin
Zhu, Ling
Gao, Peng
Hao, Yuqiu
author_facet Dong, Hongna
Yang, Wei
Li, Wei
Zhu, Simin
Zhu, Ling
Gao, Peng
Hao, Yuqiu
author_sort Dong, Hongna
collection PubMed
description Asthma is a heterogeneous airway disease characterized by airway inflammation and hyperresponsiveness. Autophagy is a self-degrading process that helps maintain cellular homeostasis. Dysregulation of autophagy is involved in the pathogenesis of many diseases. In the context of asthma, autophagy has been shown to be associated with inflammation, airway remodeling, and responsiveness to drug therapy. In-depth characterization of the role of autophagy in asthma can enhance the understanding of the pathogenesis, and provide a theoretical basis for the development of new biomarkers and targeted therapy for asthma. In this article, we focus on the relationship of autophagy and asthma, and discuss its implications for asthma pathogenesis and treatment.
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spelling pubmed-101179732023-04-21 New insights into autophagy in inflammatory subtypes of asthma Dong, Hongna Yang, Wei Li, Wei Zhu, Simin Zhu, Ling Gao, Peng Hao, Yuqiu Front Immunol Immunology Asthma is a heterogeneous airway disease characterized by airway inflammation and hyperresponsiveness. Autophagy is a self-degrading process that helps maintain cellular homeostasis. Dysregulation of autophagy is involved in the pathogenesis of many diseases. In the context of asthma, autophagy has been shown to be associated with inflammation, airway remodeling, and responsiveness to drug therapy. In-depth characterization of the role of autophagy in asthma can enhance the understanding of the pathogenesis, and provide a theoretical basis for the development of new biomarkers and targeted therapy for asthma. In this article, we focus on the relationship of autophagy and asthma, and discuss its implications for asthma pathogenesis and treatment. Frontiers Media S.A. 2023-04-06 /pmc/articles/PMC10117973/ /pubmed/37090692 http://dx.doi.org/10.3389/fimmu.2023.1156086 Text en Copyright © 2023 Dong, Yang, Li, Zhu, Zhu, Gao and Hao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Dong, Hongna
Yang, Wei
Li, Wei
Zhu, Simin
Zhu, Ling
Gao, Peng
Hao, Yuqiu
New insights into autophagy in inflammatory subtypes of asthma
title New insights into autophagy in inflammatory subtypes of asthma
title_full New insights into autophagy in inflammatory subtypes of asthma
title_fullStr New insights into autophagy in inflammatory subtypes of asthma
title_full_unstemmed New insights into autophagy in inflammatory subtypes of asthma
title_short New insights into autophagy in inflammatory subtypes of asthma
title_sort new insights into autophagy in inflammatory subtypes of asthma
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10117973/
https://www.ncbi.nlm.nih.gov/pubmed/37090692
http://dx.doi.org/10.3389/fimmu.2023.1156086
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