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COVID-19, maternal, and neonatal outcomes: National Mother-Child Cohort (NMCC) of K-COV-N cohort in South Korea

Throughout the COVID-19 pandemic, pregnant women have been classified as a vulnerable population. However, the evidence on the effect of infection during pregnancy on maternal and neonatal outcomes is still uncertain, and related research comprising a large population of pregnant women in Asian coun...

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Autores principales: Oh, Jongmin, Lee, Whanhee, Kim, Choong-jong, Kim, Yi Jun, Park, Hyesook, Lee, Ji Hyen, Park, Mi Hye, Lee, Seulbi, Ha, Eunhee, Lee, Kyung A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118124/
https://www.ncbi.nlm.nih.gov/pubmed/37079650
http://dx.doi.org/10.1371/journal.pone.0284779
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author Oh, Jongmin
Lee, Whanhee
Kim, Choong-jong
Kim, Yi Jun
Park, Hyesook
Lee, Ji Hyen
Park, Mi Hye
Lee, Seulbi
Ha, Eunhee
Lee, Kyung A.
author_facet Oh, Jongmin
Lee, Whanhee
Kim, Choong-jong
Kim, Yi Jun
Park, Hyesook
Lee, Ji Hyen
Park, Mi Hye
Lee, Seulbi
Ha, Eunhee
Lee, Kyung A.
author_sort Oh, Jongmin
collection PubMed
description Throughout the COVID-19 pandemic, pregnant women have been classified as a vulnerable population. However, the evidence on the effect of infection during pregnancy on maternal and neonatal outcomes is still uncertain, and related research comprising a large population of pregnant women in Asian countries is limited. We constructed a national cohort including mothers and children (369,887 pairs) registered in the Prevention Agency-COVID-19-National Health Insurance Service (COV-N), from January 1, 2020 to March 31, 2022. We performed propensity score matchings and generalized estimation equation models to estimate the effect of COVID-19 on maternal and neonatal outcomes. In summary, we found little evidence of the effect of COVID-19 infection during pregnancy on maternal and neonatal outcomes; however, a relationship between COVID-19 infection in the second trimester and postpartum hemorrhages was discovered (Odds ratio (OR) of Delta period: 2.26, 95% Confidence intervals (CI): 1.26, 4.05). In addition, neonatal intensive care unit (NICU) admissions increased due to COVID-19 infection (pre-Delta period: 2.31, 95% CI: 1.31, 4.10; Delta period: 1.99, 95% CI: 1.47, 2.69; Omicron period: 2.36, 95% CI: 1.75, 3.18). Based on the national retrospective cohort study data, this study investigated the effects of COVID-19 infection on maternal and neonatal outcomes in Korea from the pre-Delta to the initial Omicron epidemic periods. Our evidence suggests that the timely and successful policies of the government and academia in response to COVID-19 infections in newborns in Korea may cause an increase in NICU admissions, but nonetheless, they prevent adverse maternal and neonatal outcomes simultaneously.
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spelling pubmed-101181242023-04-21 COVID-19, maternal, and neonatal outcomes: National Mother-Child Cohort (NMCC) of K-COV-N cohort in South Korea Oh, Jongmin Lee, Whanhee Kim, Choong-jong Kim, Yi Jun Park, Hyesook Lee, Ji Hyen Park, Mi Hye Lee, Seulbi Ha, Eunhee Lee, Kyung A. PLoS One Research Article Throughout the COVID-19 pandemic, pregnant women have been classified as a vulnerable population. However, the evidence on the effect of infection during pregnancy on maternal and neonatal outcomes is still uncertain, and related research comprising a large population of pregnant women in Asian countries is limited. We constructed a national cohort including mothers and children (369,887 pairs) registered in the Prevention Agency-COVID-19-National Health Insurance Service (COV-N), from January 1, 2020 to March 31, 2022. We performed propensity score matchings and generalized estimation equation models to estimate the effect of COVID-19 on maternal and neonatal outcomes. In summary, we found little evidence of the effect of COVID-19 infection during pregnancy on maternal and neonatal outcomes; however, a relationship between COVID-19 infection in the second trimester and postpartum hemorrhages was discovered (Odds ratio (OR) of Delta period: 2.26, 95% Confidence intervals (CI): 1.26, 4.05). In addition, neonatal intensive care unit (NICU) admissions increased due to COVID-19 infection (pre-Delta period: 2.31, 95% CI: 1.31, 4.10; Delta period: 1.99, 95% CI: 1.47, 2.69; Omicron period: 2.36, 95% CI: 1.75, 3.18). Based on the national retrospective cohort study data, this study investigated the effects of COVID-19 infection on maternal and neonatal outcomes in Korea from the pre-Delta to the initial Omicron epidemic periods. Our evidence suggests that the timely and successful policies of the government and academia in response to COVID-19 infections in newborns in Korea may cause an increase in NICU admissions, but nonetheless, they prevent adverse maternal and neonatal outcomes simultaneously. Public Library of Science 2023-04-20 /pmc/articles/PMC10118124/ /pubmed/37079650 http://dx.doi.org/10.1371/journal.pone.0284779 Text en © 2023 Oh et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Oh, Jongmin
Lee, Whanhee
Kim, Choong-jong
Kim, Yi Jun
Park, Hyesook
Lee, Ji Hyen
Park, Mi Hye
Lee, Seulbi
Ha, Eunhee
Lee, Kyung A.
COVID-19, maternal, and neonatal outcomes: National Mother-Child Cohort (NMCC) of K-COV-N cohort in South Korea
title COVID-19, maternal, and neonatal outcomes: National Mother-Child Cohort (NMCC) of K-COV-N cohort in South Korea
title_full COVID-19, maternal, and neonatal outcomes: National Mother-Child Cohort (NMCC) of K-COV-N cohort in South Korea
title_fullStr COVID-19, maternal, and neonatal outcomes: National Mother-Child Cohort (NMCC) of K-COV-N cohort in South Korea
title_full_unstemmed COVID-19, maternal, and neonatal outcomes: National Mother-Child Cohort (NMCC) of K-COV-N cohort in South Korea
title_short COVID-19, maternal, and neonatal outcomes: National Mother-Child Cohort (NMCC) of K-COV-N cohort in South Korea
title_sort covid-19, maternal, and neonatal outcomes: national mother-child cohort (nmcc) of k-cov-n cohort in south korea
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118124/
https://www.ncbi.nlm.nih.gov/pubmed/37079650
http://dx.doi.org/10.1371/journal.pone.0284779
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