Obscurin Rho GEF domains are phosphorylated by MST-family kinases but do not exhibit nucleotide exchange factor activity towards Rho GTPases in vitro

Obscurin is a giant muscle protein (>800 kDa) featuring multiple signalling domains, including an SH3-DH-PH domain triplet from the Trio-subfamily of guanosine nucleotide exchange factors (GEFs). While previous research suggests that these domains can activate the small GTPases RhoA and RhoQ in c...

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Detalles Bibliográficos
Autores principales: Koch, Daniel, Kho, Ay Lin, Fukuzawa, Atsushi, Alexandrovich, Alexander, Vanaanen, Kutti J., Beavil, Andrew, Pfuhl, Mark, Rees, Martin, Gautel, Mathias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118190/
https://www.ncbi.nlm.nih.gov/pubmed/37079638
http://dx.doi.org/10.1371/journal.pone.0284453

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