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Tick saliva and its role in pathogen transmission
Tick saliva is a complex mixture of peptidic and non-peptidic molecules that aid engorgement. The composition of tick saliva changes as feeding progresses and the tick counters the dynamic host response. Ixodid ticks such as Ixodes ricinus, the most important tick species in Europe, transmit numerou...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Vienna
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118219/ https://www.ncbi.nlm.nih.gov/pubmed/31062185 http://dx.doi.org/10.1007/s00508-019-1500-y |
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author | Nuttall, Patricia A. |
author_facet | Nuttall, Patricia A. |
author_sort | Nuttall, Patricia A. |
collection | PubMed |
description | Tick saliva is a complex mixture of peptidic and non-peptidic molecules that aid engorgement. The composition of tick saliva changes as feeding progresses and the tick counters the dynamic host response. Ixodid ticks such as Ixodes ricinus, the most important tick species in Europe, transmit numerous pathogens that cause debilitating diseases, e.g. Lyme borreliosis and tick-borne encephalitis. Tick-borne pathogens are transmitted in tick saliva during blood feeding; however, saliva is not simply a medium enabling pathogen transfer. Instead, tick-borne pathogens exploit saliva-induced modulation of host responses to promote their transmission and infection, so-called saliva-assisted transmission (SAT). Characterization of the saliva factors that facilitate SAT is an active area of current research. Besides providing new insights into how tick-borne pathogens survive in nature, the research is opening new avenues for vaccine development. |
format | Online Article Text |
id | pubmed-10118219 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer Vienna |
record_format | MEDLINE/PubMed |
spelling | pubmed-101182192023-04-22 Tick saliva and its role in pathogen transmission Nuttall, Patricia A. Wien Klin Wochenschr Lyme Borreliosis Tick saliva is a complex mixture of peptidic and non-peptidic molecules that aid engorgement. The composition of tick saliva changes as feeding progresses and the tick counters the dynamic host response. Ixodid ticks such as Ixodes ricinus, the most important tick species in Europe, transmit numerous pathogens that cause debilitating diseases, e.g. Lyme borreliosis and tick-borne encephalitis. Tick-borne pathogens are transmitted in tick saliva during blood feeding; however, saliva is not simply a medium enabling pathogen transfer. Instead, tick-borne pathogens exploit saliva-induced modulation of host responses to promote their transmission and infection, so-called saliva-assisted transmission (SAT). Characterization of the saliva factors that facilitate SAT is an active area of current research. Besides providing new insights into how tick-borne pathogens survive in nature, the research is opening new avenues for vaccine development. Springer Vienna 2019-05-06 2023 /pmc/articles/PMC10118219/ /pubmed/31062185 http://dx.doi.org/10.1007/s00508-019-1500-y Text en © The Author(s) 2019 https://creativecommons.org/licenses/by/4.0/Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Lyme Borreliosis Nuttall, Patricia A. Tick saliva and its role in pathogen transmission |
title | Tick saliva and its role in pathogen transmission |
title_full | Tick saliva and its role in pathogen transmission |
title_fullStr | Tick saliva and its role in pathogen transmission |
title_full_unstemmed | Tick saliva and its role in pathogen transmission |
title_short | Tick saliva and its role in pathogen transmission |
title_sort | tick saliva and its role in pathogen transmission |
topic | Lyme Borreliosis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118219/ https://www.ncbi.nlm.nih.gov/pubmed/31062185 http://dx.doi.org/10.1007/s00508-019-1500-y |
work_keys_str_mv | AT nuttallpatriciaa ticksalivaanditsroleinpathogentransmission |