Comparison of Protein Particle Formation in IgG1 mAbs Formulated with PS20 Vs. PS80 When Subjected to Interfacial Dilatational Stress

Polysorbates (PS) are nonionic surfactants that are commonly included in protein formulations to mitigate the formation of interfacial stress-induced protein particles and thus increase their long-term storage stability. Nonetheless, factors that dictate the efficiency of different polysorbates in m...

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Detalles Bibliográficos
Autores principales: Vaclaw, Coleman, Merritt, Kimberly, Griffin, Valerie P., Whitaker, Neal, Gokhale, Madhushree, Volkin, David B., Ogunyankin, Maria O., Dhar, Prajnaparamita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118229/
https://www.ncbi.nlm.nih.gov/pubmed/37081185
http://dx.doi.org/10.1208/s12249-023-02561-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118229/
https://www.ncbi.nlm.nih.gov/pubmed/37081185
http://dx.doi.org/10.1208/s12249-023-02561-4

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