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Action of enfuvirtide on the pregnancy of albino rats ( Rattus norvegicus albinus, Rodentia, Mammalia ): biological assay and functional and histological analyses of exposed maternal-fetal organs

OBJECTIVE: To assess the effects of enfuvirtide on pregnancy in albino rats and their fetuses. METHODS: Forty pregnant EPM 1 Wistar rats were randomly allocated into four groups: control (E) (distilled water twice/day), G1 (4mg/kg/day enfuvirtide), G2 (12mg/kg/day enfuvirtide), and G3 (36mg/kg/day e...

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Autores principales: de Moraes, Renata Delphim, Araujo, Edward, Castelo, Adauto, Peixoto, Alberto Borges, Amed, Abês Mahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Israelita de Ensino e Pesquisa Albert Einstein 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118372/
https://www.ncbi.nlm.nih.gov/pubmed/37075461
http://dx.doi.org/10.31744/einstein_journal/2023AO0230
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author de Moraes, Renata Delphim
Araujo, Edward
Castelo, Adauto
Peixoto, Alberto Borges
Amed, Abês Mahmed
author_facet de Moraes, Renata Delphim
Araujo, Edward
Castelo, Adauto
Peixoto, Alberto Borges
Amed, Abês Mahmed
author_sort de Moraes, Renata Delphim
collection PubMed
description OBJECTIVE: To assess the effects of enfuvirtide on pregnancy in albino rats and their fetuses. METHODS: Forty pregnant EPM 1 Wistar rats were randomly allocated into four groups: control (E) (distilled water twice/day), G1 (4mg/kg/day enfuvirtide), G2 (12mg/kg/day enfuvirtide), and G3 (36mg/kg/day enfuvirtide) groups. On the 20th day of gestation, the rats were anesthetized and subjected to cesarean section. Their blood was collected for laboratory analysis, and they were sacrificed. The offspring’s fragments of their kidneys, liver, and placentas and the maternal rats’ fragments of their lungs, kidneys, and liver were separated in the immediate postpartum period for light microscopy analysis. RESULTS: No maternal deaths occurred. In the second week at the end of pregnancy, the mean weight of the G3 Group was significantly lower than that of the G2 Group (p=0.029 and p=0.028, respectively). Analyzing blood laboratory parameters, the G1 Group had the lowest mean amylase level, and the G2 Group had the lowest mean hemoglobin level and the highest mean platelet count. In the morphological analysis, there were no changes in organs, such as the kidneys and liver, in both the maternal rats and offspring. Three maternal rats in the G3 Group had pulmonary inflammation in the lungs. CONCLUSION: Enfuvirtide has no significant adverse effects on pregnancy, conceptual products, or functional alterations in maternal rats.
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spelling pubmed-101183722023-04-21 Action of enfuvirtide on the pregnancy of albino rats ( Rattus norvegicus albinus, Rodentia, Mammalia ): biological assay and functional and histological analyses of exposed maternal-fetal organs de Moraes, Renata Delphim Araujo, Edward Castelo, Adauto Peixoto, Alberto Borges Amed, Abês Mahmed Einstein (Sao Paulo) Original Article OBJECTIVE: To assess the effects of enfuvirtide on pregnancy in albino rats and their fetuses. METHODS: Forty pregnant EPM 1 Wistar rats were randomly allocated into four groups: control (E) (distilled water twice/day), G1 (4mg/kg/day enfuvirtide), G2 (12mg/kg/day enfuvirtide), and G3 (36mg/kg/day enfuvirtide) groups. On the 20th day of gestation, the rats were anesthetized and subjected to cesarean section. Their blood was collected for laboratory analysis, and they were sacrificed. The offspring’s fragments of their kidneys, liver, and placentas and the maternal rats’ fragments of their lungs, kidneys, and liver were separated in the immediate postpartum period for light microscopy analysis. RESULTS: No maternal deaths occurred. In the second week at the end of pregnancy, the mean weight of the G3 Group was significantly lower than that of the G2 Group (p=0.029 and p=0.028, respectively). Analyzing blood laboratory parameters, the G1 Group had the lowest mean amylase level, and the G2 Group had the lowest mean hemoglobin level and the highest mean platelet count. In the morphological analysis, there were no changes in organs, such as the kidneys and liver, in both the maternal rats and offspring. Three maternal rats in the G3 Group had pulmonary inflammation in the lungs. CONCLUSION: Enfuvirtide has no significant adverse effects on pregnancy, conceptual products, or functional alterations in maternal rats. Instituto Israelita de Ensino e Pesquisa Albert Einstein 2023-03-24 /pmc/articles/PMC10118372/ /pubmed/37075461 http://dx.doi.org/10.31744/einstein_journal/2023AO0230 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
de Moraes, Renata Delphim
Araujo, Edward
Castelo, Adauto
Peixoto, Alberto Borges
Amed, Abês Mahmed
Action of enfuvirtide on the pregnancy of albino rats ( Rattus norvegicus albinus, Rodentia, Mammalia ): biological assay and functional and histological analyses of exposed maternal-fetal organs
title Action of enfuvirtide on the pregnancy of albino rats ( Rattus norvegicus albinus, Rodentia, Mammalia ): biological assay and functional and histological analyses of exposed maternal-fetal organs
title_full Action of enfuvirtide on the pregnancy of albino rats ( Rattus norvegicus albinus, Rodentia, Mammalia ): biological assay and functional and histological analyses of exposed maternal-fetal organs
title_fullStr Action of enfuvirtide on the pregnancy of albino rats ( Rattus norvegicus albinus, Rodentia, Mammalia ): biological assay and functional and histological analyses of exposed maternal-fetal organs
title_full_unstemmed Action of enfuvirtide on the pregnancy of albino rats ( Rattus norvegicus albinus, Rodentia, Mammalia ): biological assay and functional and histological analyses of exposed maternal-fetal organs
title_short Action of enfuvirtide on the pregnancy of albino rats ( Rattus norvegicus albinus, Rodentia, Mammalia ): biological assay and functional and histological analyses of exposed maternal-fetal organs
title_sort action of enfuvirtide on the pregnancy of albino rats ( rattus norvegicus albinus, rodentia, mammalia ): biological assay and functional and histological analyses of exposed maternal-fetal organs
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118372/
https://www.ncbi.nlm.nih.gov/pubmed/37075461
http://dx.doi.org/10.31744/einstein_journal/2023AO0230
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