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Evolution to permanent or transient conditions in children with positive neonatal TSH screening tests in Sergipe, Brazil
OBJECTIVES: To assess the evolution to permanent or transient conditions in children with positive neonatal TSH tests in Sergipe, Brazil, from 2004 to 2010. SUBJECTS AND METHODS: Out of 193,794 screened newborns, 713 presented a neonatal TSH level higher than the local cutoff (5.2 µU/mL). From the c...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Endocrinologia e Metabologia
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118637/ https://www.ncbi.nlm.nih.gov/pubmed/27812608 http://dx.doi.org/10.1590/2359-3997000000189 |
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author | Matos, Diana M. Ramalho, Roberto J. R. Carvalho, Bruno M. Almeida, Maria Augusta C. T. Passos, Luciana F. D. Vasconcelos, Talmay T. S. Melo, Enaldo V. Oliveira, Carla R. P. Santos, Elenilde G. Resende, Karla F. Aguiar-Oliveira, Manuel H. |
author_facet | Matos, Diana M. Ramalho, Roberto J. R. Carvalho, Bruno M. Almeida, Maria Augusta C. T. Passos, Luciana F. D. Vasconcelos, Talmay T. S. Melo, Enaldo V. Oliveira, Carla R. P. Santos, Elenilde G. Resende, Karla F. Aguiar-Oliveira, Manuel H. |
author_sort | Matos, Diana M. |
collection | PubMed |
description | OBJECTIVES: To assess the evolution to permanent or transient conditions in children with positive neonatal TSH tests in Sergipe, Brazil, from 2004 to 2010. SUBJECTS AND METHODS: Out of 193,794 screened newborns, 713 presented a neonatal TSH level higher than the local cutoff (5.2 µU/mL). From the confirmatory serum TSH values, the children were diagnosed with initial congenital hypothyroidism (CH) or suspect CH. From the evolution, they were classified as permanent CH, hyperthyrotropinemia, or transient TSH elevation. The mean incidence of each final condition was calculated for the total period of time. RESULTS: The initial diagnosis included 37 CH (18.1%) and 167 suspect CH (81.9%) cases. The final diagnosis included 46 cases of permanent CH (22.5%), 56 of hyperthyrotropinemia (27.5%), and 102 of transient TSH elevation (50.0%). Out of the 37 cases of initial CH, 23 (62.2%) had permanent CH, nine (24.3%) had hyperthyrotropinemia, and five (13.5%) had transient TSH elevation. Out of the 167 suspect CH cases, 23 (13.8%) had permanent CH, 47 (28.1%) had hyperthyrotropinemia and 97 (58.1%) had transient TSH elevation. The mean incidence after the follow up was 1:4,166 for permanent CH, 1:3,448 for hyperthyrotropinemia, and 1:1,887 for transient TSH elevation. Eighty-six percent of the children with an initial diagnosis of CH and 41.9% with suspect CH had a permanent condition (CH or hyperthyrotropinemia). CONCLUSIONS: The follow-up of children with an initial diagnosis of CH or suspect CH is necessary to determine whether the disorder is permanent because predicting the evolution of the condition is difficult. |
format | Online Article Text |
id | pubmed-10118637 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Sociedade Brasileira de Endocrinologia e Metabologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-101186372023-04-21 Evolution to permanent or transient conditions in children with positive neonatal TSH screening tests in Sergipe, Brazil Matos, Diana M. Ramalho, Roberto J. R. Carvalho, Bruno M. Almeida, Maria Augusta C. T. Passos, Luciana F. D. Vasconcelos, Talmay T. S. Melo, Enaldo V. Oliveira, Carla R. P. Santos, Elenilde G. Resende, Karla F. Aguiar-Oliveira, Manuel H. Arch Endocrinol Metab Articles OBJECTIVES: To assess the evolution to permanent or transient conditions in children with positive neonatal TSH tests in Sergipe, Brazil, from 2004 to 2010. SUBJECTS AND METHODS: Out of 193,794 screened newborns, 713 presented a neonatal TSH level higher than the local cutoff (5.2 µU/mL). From the confirmatory serum TSH values, the children were diagnosed with initial congenital hypothyroidism (CH) or suspect CH. From the evolution, they were classified as permanent CH, hyperthyrotropinemia, or transient TSH elevation. The mean incidence of each final condition was calculated for the total period of time. RESULTS: The initial diagnosis included 37 CH (18.1%) and 167 suspect CH (81.9%) cases. The final diagnosis included 46 cases of permanent CH (22.5%), 56 of hyperthyrotropinemia (27.5%), and 102 of transient TSH elevation (50.0%). Out of the 37 cases of initial CH, 23 (62.2%) had permanent CH, nine (24.3%) had hyperthyrotropinemia, and five (13.5%) had transient TSH elevation. Out of the 167 suspect CH cases, 23 (13.8%) had permanent CH, 47 (28.1%) had hyperthyrotropinemia and 97 (58.1%) had transient TSH elevation. The mean incidence after the follow up was 1:4,166 for permanent CH, 1:3,448 for hyperthyrotropinemia, and 1:1,887 for transient TSH elevation. Eighty-six percent of the children with an initial diagnosis of CH and 41.9% with suspect CH had a permanent condition (CH or hyperthyrotropinemia). CONCLUSIONS: The follow-up of children with an initial diagnosis of CH or suspect CH is necessary to determine whether the disorder is permanent because predicting the evolution of the condition is difficult. Sociedade Brasileira de Endocrinologia e Metabologia 2016-08-23 /pmc/articles/PMC10118637/ /pubmed/27812608 http://dx.doi.org/10.1590/2359-3997000000189 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Matos, Diana M. Ramalho, Roberto J. R. Carvalho, Bruno M. Almeida, Maria Augusta C. T. Passos, Luciana F. D. Vasconcelos, Talmay T. S. Melo, Enaldo V. Oliveira, Carla R. P. Santos, Elenilde G. Resende, Karla F. Aguiar-Oliveira, Manuel H. Evolution to permanent or transient conditions in children with positive neonatal TSH screening tests in Sergipe, Brazil |
title | Evolution to permanent or transient conditions in children with positive neonatal TSH screening tests in Sergipe, Brazil |
title_full | Evolution to permanent or transient conditions in children with positive neonatal TSH screening tests in Sergipe, Brazil |
title_fullStr | Evolution to permanent or transient conditions in children with positive neonatal TSH screening tests in Sergipe, Brazil |
title_full_unstemmed | Evolution to permanent or transient conditions in children with positive neonatal TSH screening tests in Sergipe, Brazil |
title_short | Evolution to permanent or transient conditions in children with positive neonatal TSH screening tests in Sergipe, Brazil |
title_sort | evolution to permanent or transient conditions in children with positive neonatal tsh screening tests in sergipe, brazil |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118637/ https://www.ncbi.nlm.nih.gov/pubmed/27812608 http://dx.doi.org/10.1590/2359-3997000000189 |
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