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3T magnetic resonance spectroscopy as a powerful diagnostic modality for assessment of thyroid nodules

OBJECTIVE: Magnetic resonance spectroscopy (MRS) is a powerful tool for structural studies of chemical compounds and biomolecules and also documented promising findings as a potential imaging technology in thyroid oncology. This prospective study was to ascertain the clinical significance of 3 Tesla...

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Autores principales: Aghaghazvini, Leila, Pirouzi, Pirouz, Sharifian, Hashem, Yazdani, Nasrin, Kooraki, Soheil, Ghadiri, Afsoon, Assadi, Majid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Endocrinologia e Metabologia 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118653/
https://www.ncbi.nlm.nih.gov/pubmed/30462802
http://dx.doi.org/10.20945/2359-3997000000069
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author Aghaghazvini, Leila
Pirouzi, Pirouz
Sharifian, Hashem
Yazdani, Nasrin
Kooraki, Soheil
Ghadiri, Afsoon
Assadi, Majid
author_facet Aghaghazvini, Leila
Pirouzi, Pirouz
Sharifian, Hashem
Yazdani, Nasrin
Kooraki, Soheil
Ghadiri, Afsoon
Assadi, Majid
author_sort Aghaghazvini, Leila
collection PubMed
description OBJECTIVE: Magnetic resonance spectroscopy (MRS) is a powerful tool for structural studies of chemical compounds and biomolecules and also documented promising findings as a potential imaging technology in thyroid oncology. This prospective study was to ascertain the clinical significance of 3 Tesla MRS in the evaluation of patients with thyroid nodules (TNs) as an ancillary diagnostic technique for thyroid carcinoma. MATERIALS AND METHODS: Magnetic resonance spectroscopy at 3T at echo- times (TEs) 136 and 270 ms was carried out on 15 patients with total number of 32 TNs larger than 1 cm(3), which all were surgically resected. Choline (Chol) to creatine (Cr) ratio was assessed at 136 and 270 TEs on each nodule and a receiver operating characteristic (ROC) curve was used to determine optimal cut-off point. The findings were compared with histopathology of thyroid specimens. RESULTS: There were 23 benign and 9 malignant lesions (7 papillary and 2 follicular thyroid carcinomas). The mean values of Chol/Cr at 136 and 270 TEs was 2.28 ± 3.65 and 1.52 ± 1.67 respectively and the difference between benign and malignant nodules was only significant at 136 TEs. The study revealed that Chol/ Cr ratio cut-off point of 2.5 best correlates with histopathology results (sensitivity = 75%; specificity = 100%; PPV = 100%; NPV= 92%). CONCLUSION: This preliminary study showed that 3T magnetic resonance spectroscopy might be a specific modality for the evaluation of thyroid nodules in differentiation of benign from malignant thyroid tissue. However, a larger series would give much greater confidence that this state-of-the-art technology will worth pursuing in clinical practice.
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spelling pubmed-101186532023-04-21 3T magnetic resonance spectroscopy as a powerful diagnostic modality for assessment of thyroid nodules Aghaghazvini, Leila Pirouzi, Pirouz Sharifian, Hashem Yazdani, Nasrin Kooraki, Soheil Ghadiri, Afsoon Assadi, Majid Arch Endocrinol Metab Original Article OBJECTIVE: Magnetic resonance spectroscopy (MRS) is a powerful tool for structural studies of chemical compounds and biomolecules and also documented promising findings as a potential imaging technology in thyroid oncology. This prospective study was to ascertain the clinical significance of 3 Tesla MRS in the evaluation of patients with thyroid nodules (TNs) as an ancillary diagnostic technique for thyroid carcinoma. MATERIALS AND METHODS: Magnetic resonance spectroscopy at 3T at echo- times (TEs) 136 and 270 ms was carried out on 15 patients with total number of 32 TNs larger than 1 cm(3), which all were surgically resected. Choline (Chol) to creatine (Cr) ratio was assessed at 136 and 270 TEs on each nodule and a receiver operating characteristic (ROC) curve was used to determine optimal cut-off point. The findings were compared with histopathology of thyroid specimens. RESULTS: There were 23 benign and 9 malignant lesions (7 papillary and 2 follicular thyroid carcinomas). The mean values of Chol/Cr at 136 and 270 TEs was 2.28 ± 3.65 and 1.52 ± 1.67 respectively and the difference between benign and malignant nodules was only significant at 136 TEs. The study revealed that Chol/ Cr ratio cut-off point of 2.5 best correlates with histopathology results (sensitivity = 75%; specificity = 100%; PPV = 100%; NPV= 92%). CONCLUSION: This preliminary study showed that 3T magnetic resonance spectroscopy might be a specific modality for the evaluation of thyroid nodules in differentiation of benign from malignant thyroid tissue. However, a larger series would give much greater confidence that this state-of-the-art technology will worth pursuing in clinical practice. Sociedade Brasileira de Endocrinologia e Metabologia 2018-10-01 /pmc/articles/PMC10118653/ /pubmed/30462802 http://dx.doi.org/10.20945/2359-3997000000069 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Aghaghazvini, Leila
Pirouzi, Pirouz
Sharifian, Hashem
Yazdani, Nasrin
Kooraki, Soheil
Ghadiri, Afsoon
Assadi, Majid
3T magnetic resonance spectroscopy as a powerful diagnostic modality for assessment of thyroid nodules
title 3T magnetic resonance spectroscopy as a powerful diagnostic modality for assessment of thyroid nodules
title_full 3T magnetic resonance spectroscopy as a powerful diagnostic modality for assessment of thyroid nodules
title_fullStr 3T magnetic resonance spectroscopy as a powerful diagnostic modality for assessment of thyroid nodules
title_full_unstemmed 3T magnetic resonance spectroscopy as a powerful diagnostic modality for assessment of thyroid nodules
title_short 3T magnetic resonance spectroscopy as a powerful diagnostic modality for assessment of thyroid nodules
title_sort 3t magnetic resonance spectroscopy as a powerful diagnostic modality for assessment of thyroid nodules
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118653/
https://www.ncbi.nlm.nih.gov/pubmed/30462802
http://dx.doi.org/10.20945/2359-3997000000069
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