Cargando…
Mean platelet volume in patients with prolactinoma
OBJECTIVE: Prolactin is a multifunctional pituitary hormone. The effect of prolactin on platelet activation is not well understood. Prolactinomas are the most common type of pituitary adenomas, and they are medically responsive to dopamine agonists. Mean platelet volume (MPV) is a marker of platelet...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Endocrinologia e Metabologia
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118719/ https://www.ncbi.nlm.nih.gov/pubmed/26886093 http://dx.doi.org/10.1590/2359-3997000000054 |
_version_ | 1785028859929821184 |
---|---|
author | Tam, Abbas Ali Kaya, Cafer Başer, Hüsniye Ersoy, Reyhan Çakır, Bekir |
author_facet | Tam, Abbas Ali Kaya, Cafer Başer, Hüsniye Ersoy, Reyhan Çakır, Bekir |
author_sort | Tam, Abbas Ali |
collection | PubMed |
description | OBJECTIVE: Prolactin is a multifunctional pituitary hormone. The effect of prolactin on platelet activation is not well understood. Prolactinomas are the most common type of pituitary adenomas, and they are medically responsive to dopamine agonists. Mean platelet volume (MPV) is a marker of platelet function and activation. The aim of this study was to evaluate MPV values before and 6 months of cabergoline treatment when normoprolactinemia was achieved. SUBJECTS AND METHODS: A total of 101 newly diagnosed prolactinoma patients and 102 healthy control subjects were included in the study. Patients with hematological disorders that affect MPV and those on medications were excluded. Prolactin, platelet count and MPV levels were recorded before and 6 months after the initiation of cabergoline treatment (0.5 to 1 mg, two times a week). RESULTS: There was no significant difference in platelet count and MPV before and after 6 months of treatment with cabergoline in patients with prolactinoma compared with the control group (p > 0.05). CONCLUSION: Our results showed that MPV, a marker of platelet function, was unchanged in patients with prolactinoma. |
format | Online Article Text |
id | pubmed-10118719 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Sociedade Brasileira de Endocrinologia e Metabologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-101187192023-04-21 Mean platelet volume in patients with prolactinoma Tam, Abbas Ali Kaya, Cafer Başer, Hüsniye Ersoy, Reyhan Çakır, Bekir Arch Endocrinol Metab Original Article OBJECTIVE: Prolactin is a multifunctional pituitary hormone. The effect of prolactin on platelet activation is not well understood. Prolactinomas are the most common type of pituitary adenomas, and they are medically responsive to dopamine agonists. Mean platelet volume (MPV) is a marker of platelet function and activation. The aim of this study was to evaluate MPV values before and 6 months of cabergoline treatment when normoprolactinemia was achieved. SUBJECTS AND METHODS: A total of 101 newly diagnosed prolactinoma patients and 102 healthy control subjects were included in the study. Patients with hematological disorders that affect MPV and those on medications were excluded. Prolactin, platelet count and MPV levels were recorded before and 6 months after the initiation of cabergoline treatment (0.5 to 1 mg, two times a week). RESULTS: There was no significant difference in platelet count and MPV before and after 6 months of treatment with cabergoline in patients with prolactinoma compared with the control group (p > 0.05). CONCLUSION: Our results showed that MPV, a marker of platelet function, was unchanged in patients with prolactinoma. Sociedade Brasileira de Endocrinologia e Metabologia 2015-01-01 /pmc/articles/PMC10118719/ /pubmed/26886093 http://dx.doi.org/10.1590/2359-3997000000054 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Tam, Abbas Ali Kaya, Cafer Başer, Hüsniye Ersoy, Reyhan Çakır, Bekir Mean platelet volume in patients with prolactinoma |
title | Mean platelet volume in patients with prolactinoma |
title_full | Mean platelet volume in patients with prolactinoma |
title_fullStr | Mean platelet volume in patients with prolactinoma |
title_full_unstemmed | Mean platelet volume in patients with prolactinoma |
title_short | Mean platelet volume in patients with prolactinoma |
title_sort | mean platelet volume in patients with prolactinoma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118719/ https://www.ncbi.nlm.nih.gov/pubmed/26886093 http://dx.doi.org/10.1590/2359-3997000000054 |
work_keys_str_mv | AT tamabbasali meanplateletvolumeinpatientswithprolactinoma AT kayacafer meanplateletvolumeinpatientswithprolactinoma AT baserhusniye meanplateletvolumeinpatientswithprolactinoma AT ersoyreyhan meanplateletvolumeinpatientswithprolactinoma AT cakırbekir meanplateletvolumeinpatientswithprolactinoma |