Cargando…

Association of serum thyrotropin levels with coronary artery disease documented by quantitative coronary angiography: a transversal study

OBJECTIVE: The association between coronary artery disease (CAD) and thyroid function remains controversial. We evaluated the thyroid function and graduated well-defined CAD as confirmed by quantitative coronary angiography (CA). SUBJECTS AND METHODS: We evaluated the serum TSH, free thyroxine, free...

Descripción completa

Detalles Bibliográficos
Autores principales: Ortolani, Pedro D., Romaldini, João H., Guerra, Ricardo A., Portes, Evandro S., Meireles, George C. X., Pimenta, João
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Endocrinologia e Metabologia 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118738/
https://www.ncbi.nlm.nih.gov/pubmed/30304104
http://dx.doi.org/10.20945/2359-3997000000054
_version_ 1785028864643170304
author Ortolani, Pedro D.
Romaldini, João H.
Guerra, Ricardo A.
Portes, Evandro S.
Meireles, George C. X.
Pimenta, João
author_facet Ortolani, Pedro D.
Romaldini, João H.
Guerra, Ricardo A.
Portes, Evandro S.
Meireles, George C. X.
Pimenta, João
author_sort Ortolani, Pedro D.
collection PubMed
description OBJECTIVE: The association between coronary artery disease (CAD) and thyroid function remains controversial. We evaluated the thyroid function and graduated well-defined CAD as confirmed by quantitative coronary angiography (CA). SUBJECTS AND METHODS: We evaluated the serum TSH, free thyroxine, free triiodothyronine and thyroid antibody levels in 300 consecutive patients (age 61.6 ± 9.9 years and 54% were male) undergoing CAD diagnosis as confirmed by CA. Plaques with ≥ 50% stenosis being indicative of obstructive CAD, and patients were divided into groups according to main epicardial coronary arteries with plaques (0, 1, 2, 3). Lipid profiles and a homeostasis model assessment (HOMA-IR) were determined. RESULTS: Serum median (25% and 75% percentile) TSH levels in patients with group 2 and 3 (2.25; 1.66-3.12 mU/L and 4.99; 4.38-23.60 mU/L, respectively) had significantly higher TSH concentrations (p < 0.0001) than the group 0 (1.82; 1.35-2.51 mU/L). Furthermore, patients of group 3 had higher TSH concentration (p < 0.0001) than those of group 1 (1.60; 0.89-2.68 mU/L). Group 3 were older (64 ± 8.5 vs. 59 ± 9.5, p = 0.001), had more patients with dyslipidemia (84% versus 58%, p < 0.001), male (54% versus 44%, p = 0.01), hypertension (100% versus 86%, p < 0.001), and smoking (61% versus 33%, p < 0.001) than group 0. Multivariate stepwise logistic analysis showed TSH, age, HbA1c, and HOMA-IR were the CAD associated variables. CONCLUSIONS: In this cohort, elevated TSH levels in the high normal range or above are associated with the presence and severity of CAD besides may represent a weak CAD risk factor.
format Online
Article
Text
id pubmed-10118738
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Sociedade Brasileira de Endocrinologia e Metabologia
record_format MEDLINE/PubMed
spelling pubmed-101187382023-04-21 Association of serum thyrotropin levels with coronary artery disease documented by quantitative coronary angiography: a transversal study Ortolani, Pedro D. Romaldini, João H. Guerra, Ricardo A. Portes, Evandro S. Meireles, George C. X. Pimenta, João Arch Endocrinol Metab Original Article OBJECTIVE: The association between coronary artery disease (CAD) and thyroid function remains controversial. We evaluated the thyroid function and graduated well-defined CAD as confirmed by quantitative coronary angiography (CA). SUBJECTS AND METHODS: We evaluated the serum TSH, free thyroxine, free triiodothyronine and thyroid antibody levels in 300 consecutive patients (age 61.6 ± 9.9 years and 54% were male) undergoing CAD diagnosis as confirmed by CA. Plaques with ≥ 50% stenosis being indicative of obstructive CAD, and patients were divided into groups according to main epicardial coronary arteries with plaques (0, 1, 2, 3). Lipid profiles and a homeostasis model assessment (HOMA-IR) were determined. RESULTS: Serum median (25% and 75% percentile) TSH levels in patients with group 2 and 3 (2.25; 1.66-3.12 mU/L and 4.99; 4.38-23.60 mU/L, respectively) had significantly higher TSH concentrations (p < 0.0001) than the group 0 (1.82; 1.35-2.51 mU/L). Furthermore, patients of group 3 had higher TSH concentration (p < 0.0001) than those of group 1 (1.60; 0.89-2.68 mU/L). Group 3 were older (64 ± 8.5 vs. 59 ± 9.5, p = 0.001), had more patients with dyslipidemia (84% versus 58%, p < 0.001), male (54% versus 44%, p = 0.01), hypertension (100% versus 86%, p < 0.001), and smoking (61% versus 33%, p < 0.001) than group 0. Multivariate stepwise logistic analysis showed TSH, age, HbA1c, and HOMA-IR were the CAD associated variables. CONCLUSIONS: In this cohort, elevated TSH levels in the high normal range or above are associated with the presence and severity of CAD besides may represent a weak CAD risk factor. Sociedade Brasileira de Endocrinologia e Metabologia 2018-08-01 /pmc/articles/PMC10118738/ /pubmed/30304104 http://dx.doi.org/10.20945/2359-3997000000054 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ortolani, Pedro D.
Romaldini, João H.
Guerra, Ricardo A.
Portes, Evandro S.
Meireles, George C. X.
Pimenta, João
Association of serum thyrotropin levels with coronary artery disease documented by quantitative coronary angiography: a transversal study
title Association of serum thyrotropin levels with coronary artery disease documented by quantitative coronary angiography: a transversal study
title_full Association of serum thyrotropin levels with coronary artery disease documented by quantitative coronary angiography: a transversal study
title_fullStr Association of serum thyrotropin levels with coronary artery disease documented by quantitative coronary angiography: a transversal study
title_full_unstemmed Association of serum thyrotropin levels with coronary artery disease documented by quantitative coronary angiography: a transversal study
title_short Association of serum thyrotropin levels with coronary artery disease documented by quantitative coronary angiography: a transversal study
title_sort association of serum thyrotropin levels with coronary artery disease documented by quantitative coronary angiography: a transversal study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118738/
https://www.ncbi.nlm.nih.gov/pubmed/30304104
http://dx.doi.org/10.20945/2359-3997000000054
work_keys_str_mv AT ortolanipedrod associationofserumthyrotropinlevelswithcoronaryarterydiseasedocumentedbyquantitativecoronaryangiographyatransversalstudy
AT romaldinijoaoh associationofserumthyrotropinlevelswithcoronaryarterydiseasedocumentedbyquantitativecoronaryangiographyatransversalstudy
AT guerraricardoa associationofserumthyrotropinlevelswithcoronaryarterydiseasedocumentedbyquantitativecoronaryangiographyatransversalstudy
AT portesevandros associationofserumthyrotropinlevelswithcoronaryarterydiseasedocumentedbyquantitativecoronaryangiographyatransversalstudy
AT meirelesgeorgecx associationofserumthyrotropinlevelswithcoronaryarterydiseasedocumentedbyquantitativecoronaryangiographyatransversalstudy
AT pimentajoao associationofserumthyrotropinlevelswithcoronaryarterydiseasedocumentedbyquantitativecoronaryangiographyatransversalstudy