TRIB2 safeguards naive T cell homeostasis during aging

Naive CD4(+) T cells are more resistant to age-related loss than naive CD8(+) T cells, suggesting mechanisms that preferentially protect naive CD4(+) T cells during aging. Here, we show that TRIB2 is more abundant in naive CD4(+) than CD8(+) T cells and counteracts quiescence exit by suppressing AKT...

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Detalles Bibliográficos
Autores principales: Cao, Wenqiang, Sturmlechner, Ines, Zhang, Huimin, Jin, Jun, Hu, Bin, Jadhav, Rohit R., Fang, Fengqin, Weyand, Cornelia M., Goronzy, Jörg J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118747/
https://www.ncbi.nlm.nih.gov/pubmed/36884349
http://dx.doi.org/10.1016/j.celrep.2023.112195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118747/
https://www.ncbi.nlm.nih.gov/pubmed/36884349
http://dx.doi.org/10.1016/j.celrep.2023.112195

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