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TRIB2 safeguards naive T cell homeostasis during aging
Naive CD4(+) T cells are more resistant to age-related loss than naive CD8(+) T cells, suggesting mechanisms that preferentially protect naive CD4(+) T cells during aging. Here, we show that TRIB2 is more abundant in naive CD4(+) than CD8(+) T cells and counteracts quiescence exit by suppressing AKT...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118747/ https://www.ncbi.nlm.nih.gov/pubmed/36884349 http://dx.doi.org/10.1016/j.celrep.2023.112195 |