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Probiotic therapy outcomes in body composition of children and adolescent with obesity, a nonrandomized controlled trial

OBJECTIVE: The objective of this study was to evaluate the impact of probiotic supplementation therapy on anthropometric values and body composition of children and adolescent with obesity. SUBJECTS AND METHODS: This is a nonrandomized controlled, prospective, double-blind interventional clinical tr...

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Autores principales: Marcelo, Thaís Léo Pacheco, Pellicciari, Caroline Rosa, Artioli, Thiago Olivetti, Leiderman, Dânae Braga Diamante, Gradinar, Ana Lúcia Torloni, Mimica, Marcelo, Kochi, Cristiane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Endocrinologia e Metabologia 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118763/
https://www.ncbi.nlm.nih.gov/pubmed/36219201
http://dx.doi.org/10.20945/2359-3997000000526
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author Marcelo, Thaís Léo Pacheco
Pellicciari, Caroline Rosa
Artioli, Thiago Olivetti
Leiderman, Dânae Braga Diamante
Gradinar, Ana Lúcia Torloni
Mimica, Marcelo
Kochi, Cristiane
author_facet Marcelo, Thaís Léo Pacheco
Pellicciari, Caroline Rosa
Artioli, Thiago Olivetti
Leiderman, Dânae Braga Diamante
Gradinar, Ana Lúcia Torloni
Mimica, Marcelo
Kochi, Cristiane
author_sort Marcelo, Thaís Léo Pacheco
collection PubMed
description OBJECTIVE: The objective of this study was to evaluate the impact of probiotic supplementation therapy on anthropometric values and body composition of children and adolescent with obesity. SUBJECTS AND METHODS: This is a nonrandomized controlled, prospective, double-blind interventional clinical trial with primary data analysis. The sample comprised 44 pubertal children and adolescent (8-17 years old) with obesity. The patients were allocated to probiotic (Lactobacillus rhamnosus) or placebo group, with matching of gender and chronological age. Both groups received nutritional guidance, and were followed for six months. In all patients the anthropometric assessment was carried out by a nutritionist and data on weight, height and waist circumference (WC) were collected. Body composition was assessed using dual emission X-ray absorptiometry (DXA). RESULTS: After six months, both groups had increased weight, height but reduced body index mass (BMI) standard deviation score, with no differences between groups. After the intervention, both groups showed a reduction in the percentage of total body fat and an increase in lean mass, but only the placebo group showed a reduction in the percentage of trunk fat. However, the variation in these parameters did not differ between groups. CONCLUSIONS: The probiotic group does not seem to have benefited from supplementation. However, we suggest that this reduction in BMI SDS in both groups may have occurred due to improvements in diet because of the nutritional advice given throughout the therapy. We concluded that supplementation with this strain of probiotic was not effective in promoting weight loss or improving the body composition of this population.
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spelling pubmed-101187632023-04-21 Probiotic therapy outcomes in body composition of children and adolescent with obesity, a nonrandomized controlled trial Marcelo, Thaís Léo Pacheco Pellicciari, Caroline Rosa Artioli, Thiago Olivetti Leiderman, Dânae Braga Diamante Gradinar, Ana Lúcia Torloni Mimica, Marcelo Kochi, Cristiane Arch Endocrinol Metab Original Article OBJECTIVE: The objective of this study was to evaluate the impact of probiotic supplementation therapy on anthropometric values and body composition of children and adolescent with obesity. SUBJECTS AND METHODS: This is a nonrandomized controlled, prospective, double-blind interventional clinical trial with primary data analysis. The sample comprised 44 pubertal children and adolescent (8-17 years old) with obesity. The patients were allocated to probiotic (Lactobacillus rhamnosus) or placebo group, with matching of gender and chronological age. Both groups received nutritional guidance, and were followed for six months. In all patients the anthropometric assessment was carried out by a nutritionist and data on weight, height and waist circumference (WC) were collected. Body composition was assessed using dual emission X-ray absorptiometry (DXA). RESULTS: After six months, both groups had increased weight, height but reduced body index mass (BMI) standard deviation score, with no differences between groups. After the intervention, both groups showed a reduction in the percentage of total body fat and an increase in lean mass, but only the placebo group showed a reduction in the percentage of trunk fat. However, the variation in these parameters did not differ between groups. CONCLUSIONS: The probiotic group does not seem to have benefited from supplementation. However, we suggest that this reduction in BMI SDS in both groups may have occurred due to improvements in diet because of the nutritional advice given throughout the therapy. We concluded that supplementation with this strain of probiotic was not effective in promoting weight loss or improving the body composition of this population. Sociedade Brasileira de Endocrinologia e Metabologia 2022-10-11 /pmc/articles/PMC10118763/ /pubmed/36219201 http://dx.doi.org/10.20945/2359-3997000000526 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Marcelo, Thaís Léo Pacheco
Pellicciari, Caroline Rosa
Artioli, Thiago Olivetti
Leiderman, Dânae Braga Diamante
Gradinar, Ana Lúcia Torloni
Mimica, Marcelo
Kochi, Cristiane
Probiotic therapy outcomes in body composition of children and adolescent with obesity, a nonrandomized controlled trial
title Probiotic therapy outcomes in body composition of children and adolescent with obesity, a nonrandomized controlled trial
title_full Probiotic therapy outcomes in body composition of children and adolescent with obesity, a nonrandomized controlled trial
title_fullStr Probiotic therapy outcomes in body composition of children and adolescent with obesity, a nonrandomized controlled trial
title_full_unstemmed Probiotic therapy outcomes in body composition of children and adolescent with obesity, a nonrandomized controlled trial
title_short Probiotic therapy outcomes in body composition of children and adolescent with obesity, a nonrandomized controlled trial
title_sort probiotic therapy outcomes in body composition of children and adolescent with obesity, a nonrandomized controlled trial
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118763/
https://www.ncbi.nlm.nih.gov/pubmed/36219201
http://dx.doi.org/10.20945/2359-3997000000526
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