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Treatment options in hypoparathyroidism
Hypoparathyroidism remains the single endocrine deficiency disease that is not habitually treated with the missing hormone. In this article, we aim to provide a review of the conventional approach and the novel therapies as well as an overview of the perspectives on the treatment of this rare condit...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Endocrinologia e Metabologia
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118816/ https://www.ncbi.nlm.nih.gov/pubmed/36382754 http://dx.doi.org/10.20945/2359-3997000000554 |
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author | Sakane, Eliane Naomi Vieira, Maria Carolina Camargo Vieira, Gabriela Mazzarolo Marcondes Maeda, Sergio Setsuo |
author_facet | Sakane, Eliane Naomi Vieira, Maria Carolina Camargo Vieira, Gabriela Mazzarolo Marcondes Maeda, Sergio Setsuo |
author_sort | Sakane, Eliane Naomi |
collection | PubMed |
description | Hypoparathyroidism remains the single endocrine deficiency disease that is not habitually treated with the missing hormone. In this article, we aim to provide a review of the conventional approach and the novel therapies as well as an overview of the perspectives on the treatment of this rare condition. We conducted a literature review on the conventional therapy using vitamin D analogs and calcium salts, indications for thiazide diuretics and phosphorus binders, PTH analogs history and usage, and the drugs that are currently being tested in clinical trials. Conventional treatment involves calcium salts and vitamin D analogs. Thiazide diuretics can be used to reduce hypercalciuria in some cases. A low-phosphate diet is recommended, and phosphate binders are rarely needed. During pregnancy, a careful approach is necessary. The use of PTH analogs is a new approach despite the limitation of high cost. Studies have included modified PTH molecules, calcilytics, microencapsulation of human parathyroid cells, and allotransplantation. |
format | Online Article Text |
id | pubmed-10118816 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Sociedade Brasileira de Endocrinologia e Metabologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-101188162023-04-21 Treatment options in hypoparathyroidism Sakane, Eliane Naomi Vieira, Maria Carolina Camargo Vieira, Gabriela Mazzarolo Marcondes Maeda, Sergio Setsuo Arch Endocrinol Metab Review Hypoparathyroidism remains the single endocrine deficiency disease that is not habitually treated with the missing hormone. In this article, we aim to provide a review of the conventional approach and the novel therapies as well as an overview of the perspectives on the treatment of this rare condition. We conducted a literature review on the conventional therapy using vitamin D analogs and calcium salts, indications for thiazide diuretics and phosphorus binders, PTH analogs history and usage, and the drugs that are currently being tested in clinical trials. Conventional treatment involves calcium salts and vitamin D analogs. Thiazide diuretics can be used to reduce hypercalciuria in some cases. A low-phosphate diet is recommended, and phosphate binders are rarely needed. During pregnancy, a careful approach is necessary. The use of PTH analogs is a new approach despite the limitation of high cost. Studies have included modified PTH molecules, calcilytics, microencapsulation of human parathyroid cells, and allotransplantation. Sociedade Brasileira de Endocrinologia e Metabologia 2022-11-10 /pmc/articles/PMC10118816/ /pubmed/36382754 http://dx.doi.org/10.20945/2359-3997000000554 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Sakane, Eliane Naomi Vieira, Maria Carolina Camargo Vieira, Gabriela Mazzarolo Marcondes Maeda, Sergio Setsuo Treatment options in hypoparathyroidism |
title | Treatment options in hypoparathyroidism |
title_full | Treatment options in hypoparathyroidism |
title_fullStr | Treatment options in hypoparathyroidism |
title_full_unstemmed | Treatment options in hypoparathyroidism |
title_short | Treatment options in hypoparathyroidism |
title_sort | treatment options in hypoparathyroidism |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118816/ https://www.ncbi.nlm.nih.gov/pubmed/36382754 http://dx.doi.org/10.20945/2359-3997000000554 |
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