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Predictors of subclinical atherosclerosis evaluated by carotid intima-media thickness in asymptomatic young women with type 1 diabetes mellitus

OBJECTIVE: This study aimed to evaluate the occurrence and clinical predictors of subclinical atherosclerosis in asymptomatic, young adult women with type 1 DM. SUBJECTS AND METHODS: The study included 45 women with type 1 diabetes mellitus (DM) (aged 36 ± 9 years) who underwent carotid Doppler ultr...

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Autores principales: Kupfer, Rosane, Larrúbia, Manuella Rangel, Bussade, Isabela, Pereira, Joana Rodrigues Dantas, Lima, Giovanna A. Balarini, Epifanio, Marcio Antonio, Schettino, Claudio Domenico Sahione, Momesso, Denise Prado
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Endocrinologia e Metabologia 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118868/
https://www.ncbi.nlm.nih.gov/pubmed/28225861
http://dx.doi.org/10.1590/2359-3997000000255
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author Kupfer, Rosane
Larrúbia, Manuella Rangel
Bussade, Isabela
Pereira, Joana Rodrigues Dantas
Lima, Giovanna A. Balarini
Epifanio, Marcio Antonio
Schettino, Claudio Domenico Sahione
Momesso, Denise Prado
author_facet Kupfer, Rosane
Larrúbia, Manuella Rangel
Bussade, Isabela
Pereira, Joana Rodrigues Dantas
Lima, Giovanna A. Balarini
Epifanio, Marcio Antonio
Schettino, Claudio Domenico Sahione
Momesso, Denise Prado
author_sort Kupfer, Rosane
collection PubMed
description OBJECTIVE: This study aimed to evaluate the occurrence and clinical predictors of subclinical atherosclerosis in asymptomatic, young adult women with type 1 DM. SUBJECTS AND METHODS: The study included 45 women with type 1 diabetes mellitus (DM) (aged 36 ± 9 years) who underwent carotid Doppler ultrasound evaluation to determine the carotid artery intima-media thickness (CIMT) and to assess the occurrence of carotid artery plaques. Insulin sensitivity was assessed by estimated glucose disposal rate (eGDR), and metabolic syndrome (MS) was defined by the World Health Organization criteria. RESULTS: The cohort had a mean age of 36 ± 9 years, diabetes duration of 18.1 ± 9.5 years, and body mass index (BMI) of 24.6 ± 2.4 kg/m(2). MS was present in 44.4% of the participants. The CIMT was 0.25 ± 0.28 mm, and the prevalence of carotid artery plaques was 13%. CIMT correlated positively with hypertension (p = 0.04) and waist-to-hip ratio (r = 0.37, p = 0.012). The presence of carotid artery plaques correlated positively with age (p = 0.018) and hypertension (p = 0.017). eGDR correlated negatively with CIMT (r = -0.39, p = 0.009) and carotid plaques (p = 0.04). Albuminuria showed a correlation trend with CIMT (p = 0.06). Patients with carotid artery plaques were older, had a higher prevalence of hypertension, and lower eGDR. No correlation was found between CIMT and carotid plaques with diabetes duration, MS, BMI, cholesterol profile, glycated hemoglobin, high-sensitivity C-reactive protein, or fibrinogen. CONCLUSION: Insulin resistance, central obesity, hypertension, and older age were predictors of subclinical atherosclerosis in asymptomatic, young adult women with type 1 DM.
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spelling pubmed-101188682023-04-21 Predictors of subclinical atherosclerosis evaluated by carotid intima-media thickness in asymptomatic young women with type 1 diabetes mellitus Kupfer, Rosane Larrúbia, Manuella Rangel Bussade, Isabela Pereira, Joana Rodrigues Dantas Lima, Giovanna A. Balarini Epifanio, Marcio Antonio Schettino, Claudio Domenico Sahione Momesso, Denise Prado Arch Endocrinol Metab Articles OBJECTIVE: This study aimed to evaluate the occurrence and clinical predictors of subclinical atherosclerosis in asymptomatic, young adult women with type 1 DM. SUBJECTS AND METHODS: The study included 45 women with type 1 diabetes mellitus (DM) (aged 36 ± 9 years) who underwent carotid Doppler ultrasound evaluation to determine the carotid artery intima-media thickness (CIMT) and to assess the occurrence of carotid artery plaques. Insulin sensitivity was assessed by estimated glucose disposal rate (eGDR), and metabolic syndrome (MS) was defined by the World Health Organization criteria. RESULTS: The cohort had a mean age of 36 ± 9 years, diabetes duration of 18.1 ± 9.5 years, and body mass index (BMI) of 24.6 ± 2.4 kg/m(2). MS was present in 44.4% of the participants. The CIMT was 0.25 ± 0.28 mm, and the prevalence of carotid artery plaques was 13%. CIMT correlated positively with hypertension (p = 0.04) and waist-to-hip ratio (r = 0.37, p = 0.012). The presence of carotid artery plaques correlated positively with age (p = 0.018) and hypertension (p = 0.017). eGDR correlated negatively with CIMT (r = -0.39, p = 0.009) and carotid plaques (p = 0.04). Albuminuria showed a correlation trend with CIMT (p = 0.06). Patients with carotid artery plaques were older, had a higher prevalence of hypertension, and lower eGDR. No correlation was found between CIMT and carotid plaques with diabetes duration, MS, BMI, cholesterol profile, glycated hemoglobin, high-sensitivity C-reactive protein, or fibrinogen. CONCLUSION: Insulin resistance, central obesity, hypertension, and older age were predictors of subclinical atherosclerosis in asymptomatic, young adult women with type 1 DM. Sociedade Brasileira de Endocrinologia e Metabologia 2017-02-01 /pmc/articles/PMC10118868/ /pubmed/28225861 http://dx.doi.org/10.1590/2359-3997000000255 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Kupfer, Rosane
Larrúbia, Manuella Rangel
Bussade, Isabela
Pereira, Joana Rodrigues Dantas
Lima, Giovanna A. Balarini
Epifanio, Marcio Antonio
Schettino, Claudio Domenico Sahione
Momesso, Denise Prado
Predictors of subclinical atherosclerosis evaluated by carotid intima-media thickness in asymptomatic young women with type 1 diabetes mellitus
title Predictors of subclinical atherosclerosis evaluated by carotid intima-media thickness in asymptomatic young women with type 1 diabetes mellitus
title_full Predictors of subclinical atherosclerosis evaluated by carotid intima-media thickness in asymptomatic young women with type 1 diabetes mellitus
title_fullStr Predictors of subclinical atherosclerosis evaluated by carotid intima-media thickness in asymptomatic young women with type 1 diabetes mellitus
title_full_unstemmed Predictors of subclinical atherosclerosis evaluated by carotid intima-media thickness in asymptomatic young women with type 1 diabetes mellitus
title_short Predictors of subclinical atherosclerosis evaluated by carotid intima-media thickness in asymptomatic young women with type 1 diabetes mellitus
title_sort predictors of subclinical atherosclerosis evaluated by carotid intima-media thickness in asymptomatic young women with type 1 diabetes mellitus
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118868/
https://www.ncbi.nlm.nih.gov/pubmed/28225861
http://dx.doi.org/10.1590/2359-3997000000255
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