Smurf1 Facilitates Oxidative Stress and Fibrosis of Ligamentum Flavum by Promoting Nrf2 Ubiquitination and Degradation

Lumbar spinal stenosis (LSS), which can lead to irreversible neurologic damage and functional disability, is characterized by hypertrophy and fibrosis in the ligamentum flavum (LF). However, the underlying mechanism is still unclear. In the current study, the effect of Smurf1, a kind of E3 ubiquitin...

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Detalles Bibliográficos
Autores principales: Gu, Yifei, Hu, Jinquan, Wang, Chen, Qi, Min, Chen, Yu, Yu, Wenchao, Wang, Zhanchao, Wang, Xinwei, Yuan, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118886/
https://www.ncbi.nlm.nih.gov/pubmed/37091902
http://dx.doi.org/10.1155/2023/1164147

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