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Microscopic extrathyroid extension in papillary thyroid carcinoma: impact on response to therapy

OBJECTIVES: Evaluate the impact of microscopic extrathyroid extension (MEE) on outcome and therapy response in patients with cT1 and cT2 papillary thyroid carcinoma (PTC). SUBJECTS AND METHODS: Retrospective study of 970 consecutive patients, who underwent surgery for PTC between 2000 and 2016. All...

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Autores principales: Marques, Bernardo, Martins, Raquel G., Couto, Joana, Santos, Jacinta, Martins, Teresa, Rodrigues, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Endocrinologia e Metabologia 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118941/
https://www.ncbi.nlm.nih.gov/pubmed/32236308
http://dx.doi.org/10.20945/2359-3997000000210
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author Marques, Bernardo
Martins, Raquel G.
Couto, Joana
Santos, Jacinta
Martins, Teresa
Rodrigues, Fernando
author_facet Marques, Bernardo
Martins, Raquel G.
Couto, Joana
Santos, Jacinta
Martins, Teresa
Rodrigues, Fernando
author_sort Marques, Bernardo
collection PubMed
description OBJECTIVES: Evaluate the impact of microscopic extrathyroid extension (MEE) on outcome and therapy response in patients with cT1 and cT2 papillary thyroid carcinoma (PTC). SUBJECTS AND METHODS: Retrospective study of 970 consecutive patients, who underwent surgery for PTC between 2000 and 2016. All patients had: tumours ≤ 4 cm, apparent complete tumour resection, without clinically apparent lymph node or distant metastasis at diagnosis and nonaggressive histologic variant. RESULTS: Based on the finding of MEE, 175 (18.0%) patients were upstaged to T3. They were older (53.9 versus 50.6 years; P = 0.004) and were more prone to have multifocal tumours (38.2% versus 24.8%; P = 0.001). Radioiodine ablation therapy (RAI) was administered more often to MEE patients (92% versus 40.5%; P < 0.001), as well as prophylactic lymph node resection (35.4% versus 28.6%, P = 0.048). They were more likely to have biochemical incomplete response (4% versus 0.3%; P = 0.03) at the end of the follow-up period. There was no significant association between MEE and recurrence rate, persistence of disease or disease-specific mortality. CONCLUSION: These results support the changes made to the latest edition of the TNM staging system, regarding MEE. Although incomplete biochemical response is more common in these patients, it does not seem to affect their prognosis.
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spelling pubmed-101189412023-04-21 Microscopic extrathyroid extension in papillary thyroid carcinoma: impact on response to therapy Marques, Bernardo Martins, Raquel G. Couto, Joana Santos, Jacinta Martins, Teresa Rodrigues, Fernando Arch Endocrinol Metab Original Article OBJECTIVES: Evaluate the impact of microscopic extrathyroid extension (MEE) on outcome and therapy response in patients with cT1 and cT2 papillary thyroid carcinoma (PTC). SUBJECTS AND METHODS: Retrospective study of 970 consecutive patients, who underwent surgery for PTC between 2000 and 2016. All patients had: tumours ≤ 4 cm, apparent complete tumour resection, without clinically apparent lymph node or distant metastasis at diagnosis and nonaggressive histologic variant. RESULTS: Based on the finding of MEE, 175 (18.0%) patients were upstaged to T3. They were older (53.9 versus 50.6 years; P = 0.004) and were more prone to have multifocal tumours (38.2% versus 24.8%; P = 0.001). Radioiodine ablation therapy (RAI) was administered more often to MEE patients (92% versus 40.5%; P < 0.001), as well as prophylactic lymph node resection (35.4% versus 28.6%, P = 0.048). They were more likely to have biochemical incomplete response (4% versus 0.3%; P = 0.03) at the end of the follow-up period. There was no significant association between MEE and recurrence rate, persistence of disease or disease-specific mortality. CONCLUSION: These results support the changes made to the latest edition of the TNM staging system, regarding MEE. Although incomplete biochemical response is more common in these patients, it does not seem to affect their prognosis. Sociedade Brasileira de Endocrinologia e Metabologia 2020-03-18 /pmc/articles/PMC10118941/ /pubmed/32236308 http://dx.doi.org/10.20945/2359-3997000000210 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Marques, Bernardo
Martins, Raquel G.
Couto, Joana
Santos, Jacinta
Martins, Teresa
Rodrigues, Fernando
Microscopic extrathyroid extension in papillary thyroid carcinoma: impact on response to therapy
title Microscopic extrathyroid extension in papillary thyroid carcinoma: impact on response to therapy
title_full Microscopic extrathyroid extension in papillary thyroid carcinoma: impact on response to therapy
title_fullStr Microscopic extrathyroid extension in papillary thyroid carcinoma: impact on response to therapy
title_full_unstemmed Microscopic extrathyroid extension in papillary thyroid carcinoma: impact on response to therapy
title_short Microscopic extrathyroid extension in papillary thyroid carcinoma: impact on response to therapy
title_sort microscopic extrathyroid extension in papillary thyroid carcinoma: impact on response to therapy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118941/
https://www.ncbi.nlm.nih.gov/pubmed/32236308
http://dx.doi.org/10.20945/2359-3997000000210
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