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Diagnostic value of urinary luteinizing hormone levels in the monitoring of precocious puberty treatment

OBJECTIVE: To determine whether first-voided urinary LH (FV-ULH) – level measurement can adequately assess pubertal suppression as much as standard tests can. SUBJECTS AND METHODS: The study group included patients with central precocious puberty and rapidly progressing early puberty who received up...

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Autores principales: Yüce, Özge, Bideci, Aysun, Çelik, Nurullah, Çamurdan, Orhun, Cinaz, Peyami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Endocrinologia e Metabologia 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118943/
https://www.ncbi.nlm.nih.gov/pubmed/32236310
http://dx.doi.org/10.20945/2359-3997000000212
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author Yüce, Özge
Bideci, Aysun
Çelik, Nurullah
Çamurdan, Orhun
Cinaz, Peyami
author_facet Yüce, Özge
Bideci, Aysun
Çelik, Nurullah
Çamurdan, Orhun
Cinaz, Peyami
author_sort Yüce, Özge
collection PubMed
description OBJECTIVE: To determine whether first-voided urinary LH (FV-ULH) – level measurement can adequately assess pubertal suppression as much as standard tests can. SUBJECTS AND METHODS: The study group included patients with central precocious puberty and rapidly progressing early puberty who received up to 3 – 4 doses of GnRHa therapy monthly and did not have adequate hormonal suppression after GnRH stimulation (90-minute LH level > 4 IU/L). Design: All of the participants underwent an LHRH test just after admission to the study. According to the stimulated peak LH levels, the patients were divided into 2 groups and followed until the end of the first year of treatment. The concordance between FV-ULH and stimulated LH levels was assessed. RESULTS: The FV-ULH levels in patients with inadequate hormonal suppression were significantly high compared to patients with adequate hormonal suppression. FV-ULH levels were very strongly correlated with stimulated LH levels (r = 0.91). Its correlation with basal LH levels was significant (r = 0.65). However, this positive correlation was modestly weakened after the first year of treatment. The cutoff value for FV-ULH of 1.01 mIU/mL had the highest sensitivity (92.3%) and specificity (100%). CONCLUSION: FV-ULH levels, using more reliable and sensitive assay methods, can be used to monitor the adequacy of GnRHa therapy.
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spelling pubmed-101189432023-04-21 Diagnostic value of urinary luteinizing hormone levels in the monitoring of precocious puberty treatment Yüce, Özge Bideci, Aysun Çelik, Nurullah Çamurdan, Orhun Cinaz, Peyami Arch Endocrinol Metab Original Article OBJECTIVE: To determine whether first-voided urinary LH (FV-ULH) – level measurement can adequately assess pubertal suppression as much as standard tests can. SUBJECTS AND METHODS: The study group included patients with central precocious puberty and rapidly progressing early puberty who received up to 3 – 4 doses of GnRHa therapy monthly and did not have adequate hormonal suppression after GnRH stimulation (90-minute LH level > 4 IU/L). Design: All of the participants underwent an LHRH test just after admission to the study. According to the stimulated peak LH levels, the patients were divided into 2 groups and followed until the end of the first year of treatment. The concordance between FV-ULH and stimulated LH levels was assessed. RESULTS: The FV-ULH levels in patients with inadequate hormonal suppression were significantly high compared to patients with adequate hormonal suppression. FV-ULH levels were very strongly correlated with stimulated LH levels (r = 0.91). Its correlation with basal LH levels was significant (r = 0.65). However, this positive correlation was modestly weakened after the first year of treatment. The cutoff value for FV-ULH of 1.01 mIU/mL had the highest sensitivity (92.3%) and specificity (100%). CONCLUSION: FV-ULH levels, using more reliable and sensitive assay methods, can be used to monitor the adequacy of GnRHa therapy. Sociedade Brasileira de Endocrinologia e Metabologia 2020-03-18 /pmc/articles/PMC10118943/ /pubmed/32236310 http://dx.doi.org/10.20945/2359-3997000000212 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yüce, Özge
Bideci, Aysun
Çelik, Nurullah
Çamurdan, Orhun
Cinaz, Peyami
Diagnostic value of urinary luteinizing hormone levels in the monitoring of precocious puberty treatment
title Diagnostic value of urinary luteinizing hormone levels in the monitoring of precocious puberty treatment
title_full Diagnostic value of urinary luteinizing hormone levels in the monitoring of precocious puberty treatment
title_fullStr Diagnostic value of urinary luteinizing hormone levels in the monitoring of precocious puberty treatment
title_full_unstemmed Diagnostic value of urinary luteinizing hormone levels in the monitoring of precocious puberty treatment
title_short Diagnostic value of urinary luteinizing hormone levels in the monitoring of precocious puberty treatment
title_sort diagnostic value of urinary luteinizing hormone levels in the monitoring of precocious puberty treatment
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118943/
https://www.ncbi.nlm.nih.gov/pubmed/32236310
http://dx.doi.org/10.20945/2359-3997000000212
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