Regulation of MEK inhibitor selumetinib sensitivity by AKT phosphorylation in the novel BRAF L525R mutant

BACKGROUND: Oncogenic mutations in BRAF genes are found in approximately 5–10% of colorectal cancers. The majority of BRAF mutations are located within exons 11–15 of the catalytic kinase domains, with BRAF V600E accounting for more than 80% of the observed BRAF mutations. Sensitivity to BRAF- and m...

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Detalles Bibliográficos
Autores principales: Nakai, Chikako, Mimaki, Sachiyo, Matsushima, Koutatsu, Shinozaki, Eiji, Yamazaki, Kentaro, Muro, Kei, Yamaguchi, Kensei, Nishina, Tomohiro, Yuki, Satoshi, Shitara, Kohei, Bando, Hideaki, Suzuki, Yutaka, Akagi, Kiwamu, Nomura, Shogo, Fujii, Satoshi, Sugiyama, Masaya, Nishida, Nao, Mizokami, Masashi, Koh, Yasuhiro, Koshizaka, Takuya, Okada, Hideki, Abe, Yukiko, Ohtsu, Atsushi, Yoshino, Takayuki, Tsuchihara, Katsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119053/
https://www.ncbi.nlm.nih.gov/pubmed/36856908
http://dx.doi.org/10.1007/s10147-023-02318-w

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