Spinal astrocyte dysfunction drives motor neuron loss in late-onset spinal muscular atrophy

Spinal muscular atrophy (SMA) is a progressive neuromuscular disorder caused by a loss of the survival of motor neuron 1 (SMN1) gene, resulting in a loss of spinal motor neurons (MNs), leading to muscle weakness and wasting. The pathogenesis of MN loss in SMA and the selective vulnerability in diffe...

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Detalles Bibliográficos
Autores principales: Schmitt, Linda-Isabell, David, Christina, Steffen, Rebecca, Hezel, Stefanie, Roos, Andreas, Schara-Schmidt, Ulrike, Kleinschnitz, Christoph, Leo, Markus, Hagenacker, Tim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119066/
https://www.ncbi.nlm.nih.gov/pubmed/36930296
http://dx.doi.org/10.1007/s00401-023-02554-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119066/
https://www.ncbi.nlm.nih.gov/pubmed/36930296
http://dx.doi.org/10.1007/s00401-023-02554-4

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