Topologically associating domain boundaries are required for normal genome function

Topologically associating domain (TAD) boundaries partition the genome into distinct regulatory territories. Anecdotal evidence suggests that their disruption may interfere with normal gene expression and cause disease phenotypes(1–3), but the overall extent to which this occurs remains unknown. Her...

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Detalles Bibliográficos
Autores principales: Rajderkar, Sudha, Barozzi, Iros, Zhu, Yiwen, Hu, Rong, Zhang, Yanxiao, Li, Bin, Alcaina Caro, Ana, Fukuda-Yuzawa, Yoko, Kelman, Guy, Akeza, Adyam, Blow, Matthew J., Pham, Quan, Harrington, Anne N., Godoy, Janeth, Meky, Eman M., von Maydell, Kianna, Hunter, Riana D., Akiyama, Jennifer A., Novak, Catherine S., Plajzer-Frick, Ingrid, Afzal, Veena, Tran, Stella, Lopez-Rios, Javier, Talkowski, Michael E., Lloyd, K. C. Kent, Ren, Bing, Dickel, Diane E., Visel, Axel, Pennacchio, Len A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119121/
https://www.ncbi.nlm.nih.gov/pubmed/37081156
http://dx.doi.org/10.1038/s42003-023-04819-w

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