Aging microglia

Microglia are the tissue-resident macrophage population of the brain, specialized in supporting the CNS environment and protecting it from endogenous and exogenous insults. Nonetheless, their function declines with age, in ways that remain to be fully elucidated. Given the critical role played by mi...

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Detalles Bibliográficos
Autores principales: Antignano, Ignazio, Liu, Yingxiao, Offermann, Nina, Capasso, Melania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119228/
https://www.ncbi.nlm.nih.gov/pubmed/37081238
http://dx.doi.org/10.1007/s00018-023-04775-y
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author Antignano, Ignazio
Liu, Yingxiao
Offermann, Nina
Capasso, Melania
author_facet Antignano, Ignazio
Liu, Yingxiao
Offermann, Nina
Capasso, Melania
author_sort Antignano, Ignazio
collection PubMed
description Microglia are the tissue-resident macrophage population of the brain, specialized in supporting the CNS environment and protecting it from endogenous and exogenous insults. Nonetheless, their function declines with age, in ways that remain to be fully elucidated. Given the critical role played by microglia in neurodegenerative diseases, a better understanding of the aging microglia phenotype is an essential prerequisite in designing better preventive and therapeutic strategies. In this review, we discuss the most recent literature on microglia in aging, comparing findings in rodent models and human subjects.
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spelling pubmed-101192282023-04-22 Aging microglia Antignano, Ignazio Liu, Yingxiao Offermann, Nina Capasso, Melania Cell Mol Life Sci Review Microglia are the tissue-resident macrophage population of the brain, specialized in supporting the CNS environment and protecting it from endogenous and exogenous insults. Nonetheless, their function declines with age, in ways that remain to be fully elucidated. Given the critical role played by microglia in neurodegenerative diseases, a better understanding of the aging microglia phenotype is an essential prerequisite in designing better preventive and therapeutic strategies. In this review, we discuss the most recent literature on microglia in aging, comparing findings in rodent models and human subjects. Springer International Publishing 2023-04-21 2023 /pmc/articles/PMC10119228/ /pubmed/37081238 http://dx.doi.org/10.1007/s00018-023-04775-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Antignano, Ignazio
Liu, Yingxiao
Offermann, Nina
Capasso, Melania
Aging microglia
title Aging microglia
title_full Aging microglia
title_fullStr Aging microglia
title_full_unstemmed Aging microglia
title_short Aging microglia
title_sort aging microglia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119228/
https://www.ncbi.nlm.nih.gov/pubmed/37081238
http://dx.doi.org/10.1007/s00018-023-04775-y
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